دورية أكاديمية
أعرض في EDS

Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo.

التفاصيل البيبلوغرافية
العنوان: Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo.
المؤلفون: Choi JJ; Department of Biomedical Engineering, Columbia University, NewYork, NY10027, USA. jamesjc@gmail.com, Feshitan JA, Baseri B, Wang S, Tung YS, Borden MA, Konofagou EE
المصدر: IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2010 Jan; Vol. 57 (1), pp. 145-54. Date of Electronic Publication: 2009 Oct 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Institute Of Electrical And Electronics Engineers Country of Publication: United States NLM ID: 0012737 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-2531 (Electronic) Linking ISSN: 00189294 NLM ISO Abbreviation: IEEE Trans Biomed Eng Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Institute Of Electrical And Electronics Engineers
Original Publication: New York, IEEE Professional Technical Group on Bio-Medical Engineering.
مواضيع طبية MeSH: Microbubbles*, Blood-Brain Barrier/*diagnostic imaging , Drug Delivery Systems/*methods , Ultrasonography/*methods, Animals ; Brain Chemistry ; Echoencephalography ; Histocytochemistry ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Fluorescence ; Permeability
مستخلص: The therapeutic efficacy of neurological agents is severely limited, because large compounds do not cross the blood-brain barrier (BBB). Focused ultrasound (FUS) sonication in the presence of microbubbles has been shown to temporarily open the BBB, allowing systemically administered agents into the brain. Until now, polydispersed microbubbles (1-10 microm in diameter) were used, and, therefore, the bubble sizes better suited for inducing the opening remain unknown. Here, the FUS-induced BBB opening dependence on microbubble size is investigated. Bubbles at 1-2 and 4-5 microm in diameter were separately size-isolated using differential centrifugation before being systemically administered in mice (n = 28). The BBB opening pressure threshold was identified by varying the peak-rarefactional pressure amplitude. BBB opening was determined by fluorescence enhancement due to systemically administered, fluorescent-tagged, 3-kDa dextran. The identified threshold fell between 0.30 and 0.46 MPa in the case of 1-2 microm bubbles and between 0.15 and 0.30 MPa in the 4-5 microm case. At every pressure studied, the fluorescence was greater with the 4-5 mum than with the 1-2 microm bubbles. At 0.61 MPa, in the 1-2 microm bubble case, the fluorescence amount and area were greater in the thalamus than in the hippocampus. In conclusion, it was determined that the FUS-induced BBB opening was dependent on both the size distribution in the injected microbubble volume and the brain region targeted.
References: Ultrasound Med Biol. 2009 Jul;35(7):1148-58. (PMID: 19394756)
J Biomed Opt. 2001 Apr;6(2):141-50. (PMID: 11375723)
Am J Physiol. 1986 Dec;251(6 Pt 2):H1333-40. (PMID: 3098116)
Neuron. 2008 Jan 24;57(2):178-201. (PMID: 18215617)
J Colloid Interface Sci. 2009 Jan 15;329(2):316-24. (PMID: 18950786)
Nat Rev Neurosci. 2006 Jan;7(1):41-53. (PMID: 16371949)
Physiol Rev. 2008 Oct;88(4):1277-340. (PMID: 18923183)
Pharm Res. 2007 Sep;24(9):1733-44. (PMID: 17554607)
Exp Neurol. 1978 Feb;58(3):549-61. (PMID: 620709)
PLoS One. 2008 May 14;3(5):e2175. (PMID: 18478109)
Ultrasound Med Biol. 2007 Jan;33(1):95-104. (PMID: 17189051)
Ultrasound Med Biol. 2009 Sep;35(9):1574-86. (PMID: 19560856)
Ultrasound Med Biol. 2007 Oct;33(10):1651-60. (PMID: 17590501)
Phys Med Biol. 2005 Nov 21;50(22):5293-305. (PMID: 16264254)
Ultrasound Med Biol. 2010 Sep;36(9):1445-59. (PMID: 20800172)
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11719-23. (PMID: 16868082)
J Am Coll Cardiol. 2003 Jul 16;42(2):301-8. (PMID: 12875768)
Exp Neurol. 1976 Sep;52(3):447-58. (PMID: 954917)
Ultrasound Med Biol. 2006 Sep;32(9):1399-409. (PMID: 16965980)
Ultrason Imaging. 2008 Jul;30(3):189-200. (PMID: 19149463)
J Acoust Soc Am. 2007 Aug;122(2):1191-200. (PMID: 17672665)
Med Eng Phys. 2007 Sep;29(7):749-54. (PMID: 17035065)
J Neurosurg. 2006 Sep;105(3):445-54. (PMID: 16961141)
Phys Rev Lett. 2001 Dec 31;87(27 Pt 1):274501. (PMID: 11800883)
Int J Cancer. 2007 Aug 15;121(4):901-7. (PMID: 17437269)
Radiology. 2007 Apr;243(1):112-21. (PMID: 17392250)
Ultrasound Med Biol. 2004 Jul;30(7):979-89. (PMID: 15313330)
Ultrasound Med Biol. 2007 Dec;33(12):1978-87. (PMID: 17900793)
J Acoust Soc Am. 2004 Jun;115(6):3235-43. (PMID: 15237848)
Adv Drug Deliv Rev. 2007 Sep 30;59(11):1093-102. (PMID: 17869376)
Phys Med Biol. 2006 Feb 21;51(4):793-807. (PMID: 16467579)
Radiology. 2001 Sep;220(3):640-6. (PMID: 11526261)
Ultrasound Med Biol. 2005 Nov;31(11):1527-37. (PMID: 16286030)
Ultrasound Med Biol. 2007 Jul;33(7):1140-8. (PMID: 17478030)
Phys Med Biol. 2007 Sep 21;52(18):5509-30. (PMID: 17804879)
Ultrasound Med Biol. 2008 Jul;34(7):1093-104. (PMID: 18378064)
Ultrasound Med Biol. 2010 Jan;36(1):58-67. (PMID: 19900750)
Mol Imaging. 2007 Nov-Dec;6(6):384-92. (PMID: 18053409)
J Comp Neurol. 1994 Feb 22;340(4):566-76. (PMID: 8006217)
Exp Neurol. 1975 Dec;49(3):671-90. (PMID: 1204702)
Brain Res. 2001 Aug 10;910(1-2):81-93. (PMID: 11489257)
معلومات مُعتمدة: R01 EB009041 United States EB NIBIB NIH HHS; R21 EY018505 United States EY NEI NIH HHS; R21EY018505 United States EY NEI NIH HHS; R01EB009041 United States EB NIBIB NIH HHS
تواريخ الأحداث: Date Created: 20091023 Date Completed: 20100330 Latest Revision: 20211020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3968777
DOI: 10.1109/TBME.2009.2034533
PMID: 19846365
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-2531
DOI:10.1109/TBME.2009.2034533