دورية أكاديمية
أعرض في EDS

Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells.

التفاصيل البيبلوغرافية
العنوان: Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells.
المؤلفون: Banerjee A; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Schambach F, DeJong CS, Hammond SM, Reiner SL
المصدر: European journal of immunology [Eur J Immunol] 2010 Jan; Vol. 40 (1), pp. 225-31.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Signal Transduction*, CD4-Positive T-Lymphocytes/*immunology , MicroRNAs/*genetics , Receptor, Interferon alpha-beta/*immunology, Animals ; CD4-Positive T-Lymphocytes/cytology ; CD4-Positive T-Lymphocytes/metabolism ; Cell Differentiation ; Cells, Cultured ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Receptor, Interferon alpha-beta/metabolism
مستخلص: Micro-RNA (miR) are increasingly recognized as critical regulators of tissue-specific patterns of gene expression. CD4+ T cells lacking miR-155, for example, exhibit bias towards Th2 differentiation, indicating that the absence of individual miR could alter CD4+ T-cell differentiation. We now show that miR-155 is induced upon T-cell activation and that it promotes Th1 differentiation when over-expressed in activated CD4+ T cells. Antagonism of miR-155 leads to induction of IFN-gamma receptor alpha-chain (IFN-gammaRalpha), and a functional miR-155 target site is identified within the 3' untranslated region of IFN-gammaRalpha. These results identify IFN-gammaRalpha as a second miR-155 target in T cells and suggest that miR-155 contributes to Th1 differentiation in CD4+ T cells by inhibiting IFN-gamma signaling.
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معلومات مُعتمدة: R01 AI076458-02 United States AI NIAID NIH HHS; K12 CA076931 United States CA NCI NIH HHS; R01 AI042370 United States AI NIAID NIH HHS; CA076931 United States CA NCI NIH HHS; AI042370 United States AI NIAID NIH HHS; R01 AI076458 United States AI NIAID NIH HHS; R01 AI042370-15 United States AI NIAID NIH HHS; R01 AI042370-12 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (MicroRNAs)
0 (Mirn155 microRNA, mouse)
156986-95-7 (Receptor, Interferon alpha-beta)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20091031 Date Completed: 20100119 Latest Revision: 20220330
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC2807623
DOI: 10.1002/eji.200939381
PMID: 19877012
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4141
DOI:10.1002/eji.200939381