دورية أكاديمية
Bowel lesions in spondyloarthritides.
| العنوان: | Bowel lesions in spondyloarthritides. |
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| المؤلفون: | Rimbaş M; Gastroenterology Department, Clinic of Internal Medicine, Colentina Clinical Hospital, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. mrimbas@yahoo.com, Marinescu M, Voiosu MR |
| المصدر: | Romanian journal of internal medicine = Revue roumaine de medecine interne [Rom J Intern Med] 2009; Vol. 47 (1), pp. 75-85. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editura Academiei Române Country of Publication: Germany NLM ID: 9304507 Publication Model: Print Cited Medium: Print ISSN: 1220-4749 (Print) Linking ISSN: 12204749 NLM ISO Abbreviation: Rom J Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2016- > : Bucureşti : Editura Academiei Române Original Publication: Bucuresti : Editura Academiei Române, [1991- |
| مواضيع طبية MeSH: | Inflammatory Bowel Diseases/*complications , Spondylarthritis/*complications, Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Antirheumatic Agents/adverse effects ; Humans ; Intestinal Mucosa/drug effects ; Spondylarthritis/drug therapy |
| مستخلص: | The gut can play an important role in the pathogenesis of many rheumatic conditions; this is also true for spondyloarthropathies, ileocolonoscopic studies revealing the prevalence of histological gut inflammation in more than half of these patients. Furthermore, in patients with spondyloarthritis, an evolution to clinical inflammatory bowel disease has been observed in 20% of patients with an initial subclinical chronic gut inflammation, indicating that joint and bowel inflammation are somehow connected. The presence of chronic gut inflammation can be the first sign of Crohn's disease, and it is being speculated that early treatment of the gut inflammation could prevent this evolution when the appropriate drugs become available. Moreover, the medication employed in treating these patients has the potential of influencing the inflammatory bowel lesions, in a negative (NSAIDs) or positive way (DMARDs, corticosteroids, biologic agents), and there are reports trying to prove that the spondylarthropathic ileo-colonic inflammation represents, at least in part, iatrogenic COX-2 driven damage. Therefore, there are "obscure" fields regarding the issue of gut inflammation in spondyloarthropathies, which need focused research, but taking into consideration the complex treatment strategies applied in patients with these kinds of diseases, this is not an easy task to perform. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Antirheumatic Agents) |
| تواريخ الأحداث: | Date Created: 20091105 Date Completed: 20091211 Latest Revision: 20091104 |
| رمز التحديث: | 20240628 |
| PMID: | 19886073 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1220-4749 |
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