دورية أكاديمية
أعرض في EDS

ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.

التفاصيل البيبلوغرافية
العنوان: ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.
المؤلفون: Alaynick WA; Gene Expression Laboratory and the Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. alaynick@salk.edu, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN
المصدر: Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 2010 Feb; Vol. 24 (2), pp. 299-309. Date of Electronic Publication: 2009 Dec 04.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Endocrine Society Country of Publication: United States NLM ID: 8801431 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-9917 (Electronic) Linking ISSN: 08888809 NLM ISO Abbreviation: Mol Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Publication: Chevy Chase, MD : Endocrine Society
Original Publication: [Baltimore, MD : Endocrine Society, c1987-
مواضيع طبية MeSH: Gene Expression Regulation*, Gastric Mucosa/*metabolism , Heart/*physiology , Kidney/*metabolism , Myocardium/*metabolism , Potassium/*metabolism , Receptors, Estrogen/*physiology, Adult ; Animals ; Animals, Newborn ; Body Mass Index ; Female ; Genetic Association Studies ; Homeostasis ; Humans ; Hypertension/genetics ; Kidney/pathology ; Long QT Syndrome/genetics ; Male ; Mice ; Middle Aged ; Myocardium/pathology ; Oligonucleotide Array Sequence Analysis ; Organ Specificity ; Polymorphism, Single Nucleotide ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism ; Receptors, Estrogen/deficiency ; Receptors, Estrogen/genetics ; Stomach/pathology
مستخلص: Energy production by oxidative metabolism in kidney, stomach, and heart, is primarily expended in establishing ion gradients to drive renal electrolyte homeostasis, gastric acid secretion, and cardiac muscle contraction, respectively. In addition to orchestrating transcriptional control of oxidative metabolism, the orphan nuclear receptor, estrogen-related receptor gamma (ERRgamma), coordinates expression of genes central to ion homeostasis in oxidative tissues. Renal, gastric, and cardiac tissues subjected to genomic analysis of expression in perinatal ERRgamma null mice revealed a characteristic dysregulation of genes involved in transport processes, exemplified by the voltage-gated potassium channel, Kcne2. Consistently, ERRgamma null animals die during the first 72 h of life with elevated serum potassium, reductions in key gastric acid production markers, and cardiac arrhythmia with prolonged QT intervals. In addition, we find altered expression of several genes associated with hypertension in ERRgamma null mice. These findings suggest a potential role for genetic polymorphisms at the ERRgamma locus and ERRgamma modulators in the etiology and treatment of renal, gastric, and cardiac dysfunction.
References: Biochem Mol Biol Int. 1997 Oct;43(3):669-75. (PMID: 9352085)
Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1502-11. (PMID: 11705756)
J Neurooncol. 1998 Apr;37(2):169-76. (PMID: 9524096)
Circ Res. 2007 Mar 16;100(5):686-92. (PMID: 17293474)
Curr Top Med Chem. 2006;6(3):203-15. (PMID: 16515477)
J Biol Chem. 2000 Jul 14;275(28):21555-65. (PMID: 10764766)
J Mol Endocrinol. 2003 Dec;31(3):349-57. (PMID: 14664699)
Nature. 1997 Aug 21;388(6644):778-82. (PMID: 9285590)
Cancer Lett. 2007 Feb 8;246(1-2):129-38. (PMID: 16677757)
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W627-32. (PMID: 15980550)
Nature. 1996 Feb 1;379(6564):445-9. (PMID: 8559248)
Pediatr Neurol. 2008 Feb;38(2):73-85. (PMID: 18206787)
Biochim Biophys Acta. 1995 May 4;1235(2):461-6. (PMID: 7756356)
Exp Physiol. 2005 May;90(3):291-8. (PMID: 15653716)
Toxicol Lett. 2008 Dec 15;183(1-3):65-71. (PMID: 18992306)
Novartis Found Symp. 2005;266:186-98; discussion 198-203. (PMID: 16050269)
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13687-92. (PMID: 11717430)
Kidney Int. 2009 May;75(10):1019-30. (PMID: 19190676)
J Natl Cancer Inst. 2004 Apr 21;96(8):636-7. (PMID: 15100346)
Cell Metab. 2007 Jul;6(1):25-37. (PMID: 17618854)
Cell. 1995 Mar 10;80(5):805-11. (PMID: 7889574)
Nat Med. 2005 Aug;11(8):861-6. (PMID: 16007095)
Cardiovasc Res. 2005 Aug 15;67(3):438-47. (PMID: 15919067)
Circ Res. 2003 Feb 7;92(2):234-42. (PMID: 12574152)
Cardiovasc Res. 2002 Aug 1;55(2):361-8. (PMID: 12123775)
Mol Cell. 2002 Feb;9(2):303-13. (PMID: 11864604)
Curr Pharm Des. 2006;12(18):2285-302. (PMID: 16787255)
Nucl Recept Signal. 2007 Nov 30;5:e009. (PMID: 18174917)
Mol Endocrinol. 2003 Sep;17(9):1704-14. (PMID: 12817079)
J Pediatr. 1997 Jan;130(1):67-76. (PMID: 9003853)
J Biol Chem. 2006 Aug 18;281(33):23740-7. (PMID: 16754665)
Cell Metab. 2007 May;5(5):345-56. (PMID: 17488637)
Mol Cell Biol. 2003 Nov;23(22):7947-56. (PMID: 14585956)
Nature. 1988 Jan 7;331(6151):91-4. (PMID: 3267207)
Nat Biotechnol. 2008 Mar;26(3):343-51. (PMID: 18297058)
Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2710-8. (PMID: 17644563)
Circulation. 2000 Sep 5;102(10):1178-85. (PMID: 10973849)
J Biol Chem. 2004 Aug 6;279(32):33639-46. (PMID: 15161930)
Nat Genet. 2003 Dec;35(4):372-6. (PMID: 14608358)
Cell. 1999 Apr 16;97(2):175-87. (PMID: 10219239)
Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1418-23. (PMID: 17229846)
Cell. 2004 Oct 1;119(1):19-31. (PMID: 15454078)
Genes Dev. 2002 Jan 15;16(2):235-44. (PMID: 11799066)
J Clin Endocrinol Metab. 2005 May;90(5):3115-21. (PMID: 15713703)
Mol Cell Biol. 1999 Dec;19(12):8226-39. (PMID: 10567548)
Mech Dev. 2004 Mar;121(3):237-46. (PMID: 15003627)
Cell Metab. 2007 Jul;6(1):13-24. (PMID: 17618853)
Cell. 1994 Nov 4;79(3):407-14. (PMID: 7954808)
Toxicol Lett. 2006 Dec 1;167(2):95-105. (PMID: 17049190)
Cancer Res. 1999 Sep 15;59(18):4519-24. (PMID: 10493499)
Histochemistry. 1985;83(3):189-93. (PMID: 2412993)
Am J Physiol Cell Physiol. 2007 May;292(5):C1837-53. (PMID: 17267549)
Annu Rev Physiol. 1985;47:199-215. (PMID: 3922287)
Dev Cell. 2007 Sep;13(3):325-37. (PMID: 17765677)
Humangenetik. 1970;11(1):72-4. (PMID: 5490358)
Genes Dev. 2001 Apr 1;15(7):833-8. (PMID: 11297507)
Nature. 1996 Nov 7;384(6604):78-80. (PMID: 8900282)
Gastroenterology. 1999 Sep;117(3):605-18. (PMID: 10464136)
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10732-7. (PMID: 15247411)
Circulation. 2004 Apr 20;109(15):1834-41. (PMID: 15051636)
Genomics. 1998 Jun 1;50(2):222-8. (PMID: 9653649)
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6570-5. (PMID: 15100410)
معلومات مُعتمدة: R01 DK074652 United States DK NIDDK NIH HHS; HD027183 United States HD NICHD NIH HHS; United States HHMI Howard Hughes Medical Institute; R01 HD027183 United States HD NICHD NIH HHS; U19DK6243 United States DK NIDDK NIH HHS; T32 GM008666 United States GM NIGMS NIH HHS; GM008666 United States GM NIGMS NIH HHS; DK074652 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (ESRRG protein, human)
0 (Esrrg protein, mouse)
0 (Kcne2 protein, mouse)
0 (Potassium Channels, Voltage-Gated)
0 (Receptors, Estrogen)
RWP5GA015D (Potassium)
تواريخ الأحداث: Date Created: 20091208 Date Completed: 20100426 Latest Revision: 20211020
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC2817599
DOI: 10.1210/me.2009-0114
PMID: 19965931
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-9917
DOI:10.1210/me.2009-0114