دورية أكاديمية
ERRgamma regulates cardiac, gastric, and renal potassium homeostasis.
العنوان: | ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. |
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المؤلفون: | Alaynick WA; Gene Expression Laboratory and the Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA. alaynick@salk.edu, Way JM, Wilson SA, Benson WG, Pei L, Downes M, Yu R, Jonker JW, Holt JA, Rajpal DK, Li H, Stuart J, McPherson R, Remlinger KS, Chang CY, McDonnell DP, Evans RM, Billin AN |
المصدر: | Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 2010 Feb; Vol. 24 (2), pp. 299-309. Date of Electronic Publication: 2009 Dec 04. |
نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Endocrine Society Country of Publication: United States NLM ID: 8801431 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-9917 (Electronic) Linking ISSN: 08888809 NLM ISO Abbreviation: Mol Endocrinol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Chevy Chase, MD : Endocrine Society Original Publication: [Baltimore, MD : Endocrine Society, c1987- |
مواضيع طبية MeSH: | Gene Expression Regulation*, Gastric Mucosa/*metabolism , Heart/*physiology , Kidney/*metabolism , Myocardium/*metabolism , Potassium/*metabolism , Receptors, Estrogen/*physiology, Adult ; Animals ; Animals, Newborn ; Body Mass Index ; Female ; Genetic Association Studies ; Homeostasis ; Humans ; Hypertension/genetics ; Kidney/pathology ; Long QT Syndrome/genetics ; Male ; Mice ; Middle Aged ; Myocardium/pathology ; Oligonucleotide Array Sequence Analysis ; Organ Specificity ; Polymorphism, Single Nucleotide ; Potassium Channels, Voltage-Gated/genetics ; Potassium Channels, Voltage-Gated/metabolism ; Receptors, Estrogen/deficiency ; Receptors, Estrogen/genetics ; Stomach/pathology |
مستخلص: | Energy production by oxidative metabolism in kidney, stomach, and heart, is primarily expended in establishing ion gradients to drive renal electrolyte homeostasis, gastric acid secretion, and cardiac muscle contraction, respectively. In addition to orchestrating transcriptional control of oxidative metabolism, the orphan nuclear receptor, estrogen-related receptor gamma (ERRgamma), coordinates expression of genes central to ion homeostasis in oxidative tissues. Renal, gastric, and cardiac tissues subjected to genomic analysis of expression in perinatal ERRgamma null mice revealed a characteristic dysregulation of genes involved in transport processes, exemplified by the voltage-gated potassium channel, Kcne2. Consistently, ERRgamma null animals die during the first 72 h of life with elevated serum potassium, reductions in key gastric acid production markers, and cardiac arrhythmia with prolonged QT intervals. In addition, we find altered expression of several genes associated with hypertension in ERRgamma null mice. These findings suggest a potential role for genetic polymorphisms at the ERRgamma locus and ERRgamma modulators in the etiology and treatment of renal, gastric, and cardiac dysfunction. |
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معلومات مُعتمدة: | R01 DK074652 United States DK NIDDK NIH HHS; HD027183 United States HD NICHD NIH HHS; United States HHMI Howard Hughes Medical Institute; R01 HD027183 United States HD NICHD NIH HHS; U19DK6243 United States DK NIDDK NIH HHS; T32 GM008666 United States GM NIGMS NIH HHS; GM008666 United States GM NIGMS NIH HHS; DK074652 United States DK NIDDK NIH HHS |
المشرفين على المادة: | 0 (ESRRG protein, human) 0 (Esrrg protein, mouse) 0 (Kcne2 protein, mouse) 0 (Potassium Channels, Voltage-Gated) 0 (Receptors, Estrogen) RWP5GA015D (Potassium) |
تواريخ الأحداث: | Date Created: 20091208 Date Completed: 20100426 Latest Revision: 20211020 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC2817599 |
DOI: | 10.1210/me.2009-0114 |
PMID: | 19965931 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1944-9917 |
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DOI: | 10.1210/me.2009-0114 |