دورية أكاديمية
أعرض في EDS

Comparison of two models for evaluation histopathology of experimental renal ischemia.

التفاصيل البيبلوغرافية
العنوان: Comparison of two models for evaluation histopathology of experimental renal ischemia.
المؤلفون: Tirapelli LF; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900--CEP 14049-900, Ribeirão Preto, São Paulo, Brazil. tirapeli@fmrp.usp.br, Barione DF, Trazzi BF, Tirapelli DP, Novas PC, Silva CS, Martinez M, Costa RS, Tucci S Jr, Suaid HJ, Cologna AJ, Martins AC
المصدر: Transplantation proceedings [Transplant Proc] 2009 Dec; Vol. 41 (10), pp. 4083-7.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, N.Y. : Elsevier Science Inc.
Original Publication: New York Stratton.
مواضيع طبية MeSH: Kidney Diseases/*pathology , Reperfusion Injury/*pathology, Animals ; Basement Membrane/pathology ; Disease Models, Animal ; Kidney Cortex/pathology ; Kidney Tubules/pathology ; Kidney Tubules, Proximal/pathology ; Necrosis/pathology ; Rats ; Rats, Wistar
مستخلص: Renal ischemia/reperfusion (I/R) injury is one of the frequent causes of acute renal failure (ARF) due to the complex, interrelated sequence of events, that result in damage to and death of kidney cells. Cells of the proximal tubular epithelium are especially susceptible to I/R injury, leading to acute tubular necrosis, which plays a pivotal role in the pathogenesis of ARF. Several models have been explicated to assess morphological changes, including those of Jabonski et al. and Goujon et al. We compared the 2 models for histopathological evaluation of 30- or 120-minute periods of renal ischemia followed by 24-hour reperfusion in rats. Several changes were observed after application of the 2 models: proximal tubular cell necrosis, loss of brush border, vacuolization, denudation of tubular basement membrane as a consequence of flattening of basal cells, and presence of intratubular exfoliated cells in the lumen of proximal convoluted tubules at various stages of degeneration (karyorexis, kariopyknosis and karyolysis). Evaluating tubular lesions after 2 periods of experimental ischemia with light microscopy allowed us to conclude that the Goujon classification better characterized the main changes in cortical renal tubules after ischemia.
تواريخ الأحداث: Date Created: 20091217 Date Completed: 20100423 Latest Revision: 20091217
رمز التحديث: 20221213
DOI: 10.1016/j.transproceed.2009.09.061
PMID: 20005345
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2623
DOI:10.1016/j.transproceed.2009.09.061