دورية أكاديمية
No increased risk of cancer after coal tar treatment in patients with psoriasis or eczema.
| العنوان: | No increased risk of cancer after coal tar treatment in patients with psoriasis or eczema. |
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| المؤلفون: | Roelofzen JH; Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. J.Roelofzen@derma.umcn.nl, Aben KK, Oldenhof UT, Coenraads PJ, Alkemade HA, van de Kerkhof PC, van der Valk PG, Kiemeney LA |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 2010 Apr; Vol. 130 (4), pp. 953-61. Date of Electronic Publication: 2009 Dec 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Coal Tar/*administration & dosage , Eczema/*drug therapy , Eczema/*epidemiology , Neoplasms/*epidemiology , Psoriasis/*drug therapy , Psoriasis/*epidemiology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Coal Tar/adverse effects ; Female ; Humans ; Infant ; Infant, Newborn ; Keratolytic Agents/administration & dosage ; Keratolytic Agents/adverse effects ; Male ; Medical Records ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Surveys and Questionnaires ; Young Adult |
| مستخلص: | Coal tar is an effective treatment for psoriasis and eczema, but it contains several carcinogenic compounds. Occupational and animal studies have shown an increased risk of cancer after exposure to coal tar. Many dermatologists have abandoned this treatment for safety reasons, although the risk of cancer after coal tar in dermatological practice is unclear. This large cohort study included 13,200 patients with psoriasis and eczema. Information on skin disease and treatment, risk factors, and cancer occurrence was retrieved from medical files, questionnaires, and medical registries. Proportional hazards regression was used to evaluate differences in cancer risk by treatment modality. Patients treated with coal tar were compared with a reference category of patients treated with dermatocorticosteroids (assumed to carry no increased cancer risk). The median exposure to coal tar ointments was 6 months (range 1-300 months). Coal tar did not increase the risk of non-skin malignancies (hazard ratio (HR) 0.92; 95% confidence interval (CI) 0.78-1.09), or the risk of skin cancer (HR 1.09; 95% CI 0.69-1.72). This study has sufficient power to show that coal tar treatment is not associated with an increased risk of cancer. These results indicate that coal tar can be maintained as a safe treatment in dermatological practice. |
| المشرفين على المادة: | 0 (Keratolytic Agents) 8007-45-2 (Coal Tar) |
| تواريخ الأحداث: | Date Created: 20091218 Date Completed: 20100416 Latest Revision: 20220309 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1038/jid.2009.389 |
| PMID: | 20016499 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1523-1747 |
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| DOI: | 10.1038/jid.2009.389 |