دورية أكاديمية
Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective.
| العنوان: | Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective. |
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| المؤلفون: | Bhurruth-Alcor Y; Department of Chemistry, Imperial College Genetic Therapies Centre, Imperial College London, London SW7 2AZ, UK., Rost TH, Jorgensen MR, Rajender, Müller M, Skorve J, Berge RK, Miller AD |
| المصدر: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Feb 01; Vol. 20 (3), pp. 1252-5. Date of Electronic Publication: 2009 Dec 11. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | PPAR alpha/*metabolism , Peroxisome Proliferator-Activated Receptors/*agonists , Phospholipids/*chemical synthesis , Phospholipids/*pharmacology , Sulfides/*chemistry , Sulfides/*pharmacology, Animals ; Cell Line ; Humans ; Peroxisome Proliferator-Activated Receptors/metabolism ; Phospholipids/metabolism ; Rats ; Rats, Wistar |
| مستخلص: | Tetradecylthioacetic acid (TTA) is a modified fatty acid that appears to improve insulin sensitivity, lower blood lipid levels, enhance fatty acid oxidation and promote anti-inflammatory action in vivo, through mechanisms partly dependent upon peroxisome proliferator-activated receptors (PPARs). In order to improve the biological efficacy of TTA as a PPAR agonist, two novel phospholipid analogue lyso tetradecylthioacetyl-L-alpha-phosphatidylcholine and di-tetradecylthioacetyl-L-alpha-phosphatidylglycerol have been developed. Here we report on the syntheses of these novel phospholipids and their relative potential to act as PPAR agonists in vitro, in comparison to TTA and other positive controls. (Copyright (c) 2009 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (PPAR alpha) 0 (Peroxisome Proliferator-Activated Receptors) 0 (Phospholipids) 0 (Sulfides) 7ZU5I25S2O (1-(carboxymethylthio)tetradecane) |
| تواريخ الأحداث: | Date Created: 20091229 Date Completed: 20100920 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bmcl.2009.11.115 |
| PMID: | 20036122 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3405 |
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| DOI: | 10.1016/j.bmcl.2009.11.115 |