دورية أكاديمية
أعرض في EDS

Expanding the range of ZNF804A variants conferring risk of psychosis.

التفاصيل البيبلوغرافية
العنوان: Expanding the range of ZNF804A variants conferring risk of psychosis.
المؤلفون: Steinberg S; deCODE genetics, Reykjavik, Iceland., Mors O, Børglum AD, Gustafsson O, Werge T, Mortensen PB, Andreassen OA, Sigurdsson E, Thorgeirsson TE, Böttcher Y, Olason P, Ophoff RA, Cichon S, Gudjonsdottir IH, Pietiläinen OP, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Athanasiu L, Suvisaari J, Lonnqvist J, Paunio T, Hartmann A, Jürgens G, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Breuer R, Möller HJ, Giegling I, Glenthøj B, Rasmussen HB, Mattheisen M, Bitter I, Réthelyi JM, Sigmundsson T, Fossdal R, Thorsteinsdottir U, Ruggeri M, Tosato S, Strengman E, Kiemeney LA, Melle I, Djurovic S, Abramova L, Kaleda V, Walshe M, Bramon E, Vassos E, Li T, Fraser G, Walker N, Toulopoulou T, Yoon J, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Peltonen L, Rujescu D, Collier DA, Stefansson H, St Clair D, Stefansson K
مؤلفون مشاركون: Genetic Risk and Outcome in Psychosis
المصدر: Molecular psychiatry [Mol Psychiatry] 2011 Jan; Vol. 16 (1), pp. 59-66. Date of Electronic Publication: 2010 Jan 05.
نوع المنشور: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals
Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996-
مواضيع طبية MeSH: Anxiety Disorders/*genetics , Bipolar Disorder/*genetics , DNA Copy Number Variations/*genetics , Kruppel-Like Transcription Factors/*genetics , Schizophrenia/*genetics, Case-Control Studies ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Reference Values
مستخلص: A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10(-8)) associated with schizophrenia earlier. However, one variant, rs1344706[T], had come very close. This polymorphism, located in an intron of ZNF804A, was reported to associate with schizophrenia with a P-value of 1.6 × 10(-7), and with psychosis (schizophrenia plus bipolar disorder) with a P-value of 1.0 × 10(-8). In this study, using 5164 schizophrenia cases and 20,709 controls, we replicated the association with schizophrenia (odds ratio OR = 1.08, P = 0.0029) and, by adding bipolar disorder patients, we also confirmed the association with psychosis (added N = 609, OR = 1.09, P = 0.00065). Furthermore, as it has been proposed that variants such as rs1344706[T]-common and with low relative risk-may also serve to identify regions harboring less common, higher-risk susceptibility alleles, we searched ZNF804A for large copy number variants (CNVs) in 4235 psychosis patients, 1173 patients with other psychiatric disorders and 39,481 controls. We identified two CNVs including at least part of ZNF804A in psychosis patients and no ZNF804A CNVs in controls (P = 0.013 for association with psychosis). In addition, we found a ZNF804A CNV in an anxiety patient (P = 0.0016 for association with the larger set of psychiatric disorders).
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معلومات مُعتمدة: R01 MH078075 United States MH NIMH NIH HHS; R01MH078075 United States MH NIMH NIH HHS; PDA/02/06/016 United Kingdom DH_ Department of Health; G0901310 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 089061 United Kingdom WT_ Wellcome Trust
فهرسة مساهمة: Indexing Agency: NLM Local ID #: UKMS29706.
Investigator: RS Kahn; W Cahn; DH Linszen; L de Haan; J van Os; L Krabbendam; I Myin-Germeys; D Wiersma; R Bruggeman
المشرفين على المادة: 0 (Kruppel-Like Transcription Factors)
0 (ZNF804A protein, human)
تواريخ الأحداث: Date Created: 20100106 Date Completed: 20110419 Latest Revision: 20230604
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3242031
DOI: 10.1038/mp.2009.149
PMID: 20048749
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5578
DOI:10.1038/mp.2009.149