دورية أكاديمية
[Impairment of the cognitive faculties and the reaction capability caused by midazolam despite reversal using flumazenil].
| العنوان: | [Impairment of the cognitive faculties and the reaction capability caused by midazolam despite reversal using flumazenil]. |
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| عنوان ترانسليتريتد: | Beeinträchtigung der kognitiven Fähigkeiten und des Reaktionsvermögens durch Midazolam trotz Reversion mit Flumazenil. |
| المؤلفون: | Schlager A; Klinik für Anaesthesie und Allgemeine Intensivmedizin, Universität Innsbruck., Morawetz RF, Huber C, Furtwängler W, Luger TJ, Schreithofer D |
| المصدر: | Der Anaesthesist [Anaesthesist] 1991 Jan; Vol. 40 (1), pp. 33-8. |
| نوع المنشور: | Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial |
| اللغة: | German |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0370525 Publication Model: Print Cited Medium: Print ISSN: 0003-2417 (Print) Linking ISSN: 00032417 NLM ISO Abbreviation: Anaesthesist Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, Springer-Verlag. |
| مواضيع طبية MeSH: | Cognition/*drug effects , Flumazenil/*pharmacology , Midazolam/*antagonists & inhibitors , Reaction Time/*drug effects, Adult ; Double-Blind Method ; Female ; Humans ; Male |
| مستخلص: | Imidazobenzodiazepine (flumazenil) is a specific competitive benzodiazepine antagonist. It antagonizes the sedative-hypnotic, anticonvulsive, anxiolytic and the muscle-relaxant effects of benzodiazepines. Its efficacy is prompt and complete. In several studies rebound phenomena have been observed. It was the aim of this randomized double blind study to investigate the efficacy of flumazenil by psychometric tests. The psychometric parameters we used were cognition and choice reaction time of 12 young and healthy volunteers. Three medication groups (A, B and C) were formed for this investigation. In a cross over design all volunteers had to be treated in each of these three medication groups. Between the groups we set a test-free interval of 7 days for every volunteer. In medication group A (midazolam/flumazenil) we applied 15 mg midazolam. Reversion was performed after 60 min with 0.5 mg flumazenil. In medication group B (placebo/flumazenil) midazolam was replaced by a physiological solution of sodium chloride. In medication group C (placebo/placebo) midazolam and flumazenil were substituted by a physiological solution of sodium chloride. For the investigation of the psychometric parameters (cognition and choice reaction time) we used the so called syndrome kurz test (SKT) and the decision reaction time measuring instrument ("Entscheidungs-Reaktionszeit-Messgerät"; ERM). Psychometric investigations were performed in all groups at intervals of 5, 30, 60, 90, 120, 180 and 240 min. Our results show that cognitive abilities remain impaired up to 60 min after the administration of flumazenil. Decision time and choice reaction time improved 120 min after administration of the antagonist. In our investigation neither rebound phenomena nor agonistic reactions of flumazenil were observed.(ABSTRACT TRUNCATED AT 250 WORDS) |
| المشرفين على المادة: | 40P7XK9392 (Flumazenil) R60L0SM5BC (Midazolam) |
| تواريخ الأحداث: | Date Created: 19910101 Date Completed: 19910419 Latest Revision: 20131121 |
| رمز التحديث: | 20240627 |
| PMID: | 2006724 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0003-2417 |
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