دورية أكاديمية
[Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].
| العنوان: | [Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province]. |
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| المؤلفون: | Tong WB; Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, Sichuan, China., He JL, Sun L |
| المصدر: | Zhongguo yi miao he mian yi [Zhongguo Yi Miao He Mian Yi] 2009 Feb; Vol. 15 (1), pp. 45-8. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo ji bing yu fang kong zhi zhong xin Country of Publication: China NLM ID: 101545586 Publication Model: Print Cited Medium: Internet ISSN: 1006-916X (Print) Linking ISSN: 1006916X NLM ISO Abbreviation: Zhongguo Yi Miao He Mian Yi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhongguo ji bing yu fang kong zhi zhong xin |
| مواضيع طبية MeSH: | Mutation*, Gene Products, pol/*genetics , Hepatitis B/*virology , Hepatitis B Surface Antigens/*genetics , Hepatitis B virus/*genetics, Amino Acid Sequence ; China ; Gene Products, pol/chemistry ; Hepatitis B Surface Antigens/chemistry ; Hepatitis B virus/chemistry ; Hepatitis B virus/isolation & purification ; Humans ; Molecular Sequence Data ; Sequence Alignment |
| مستخلص: | Objective: To analyze HBV S gene/P gene mutation in 2 counties (districts) of Sichuan province. Methods: HBV DNA were extracted from sera positive both for HBsAg and HBeAg. After PCR and nucleotide sequencing, nucleotide/amino acid mutation in S and P gene were compared and analyzed. Results: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12 samples (25.53%,12/47), correlating with T126A, I126T/S, P127T, T131N, M133L, M133T and T140I; high proportion of mutation clustered in first loop of 'a' determinant (92.86%,13/14), rtV207I mutation in C domain of reverse transcription occured in one sample. Conclusion: Naturally occurring mutation in 'a' determinant clustered predominantly in the first loop and usually associated with altered antigenicity, posing a potential threat to successfully vaccinated individuals; Lamivudine-resistant mutant might occur in patient even without nucleotide analogue treatment. |
| المشرفين على المادة: | 0 (Gene Products, pol) 0 (Hepatitis B Surface Antigens) 0 (P protein, Hepatitis B virus) |
| تواريخ الأحداث: | Date Created: 20100119 Date Completed: 20100216 Latest Revision: 20160120 |
| رمز التحديث: | 20240628 |
| PMID: | 20077675 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1006-916X |
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