دورية أكاديمية
أعرض في EDS

Evaluation of late adverse events in long-term wilms' tumor survivors.

التفاصيل البيبلوغرافية
العنوان: Evaluation of late adverse events in long-term wilms' tumor survivors.
المؤلفون: van Dijk IW; Department of Radiation Oncology, Academic Medical Center, Amsterdam, the Netherlands. i.w.vandijk@amc.uva.nl, Oldenburger F, Cardous-Ubbink MC, Geenen MM, Heinen RC, de Kraker J, van Leeuwen FE, van der Pal HJ, Caron HN, Koning CC, Kremer LC
المصدر: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2010 Oct 01; Vol. 78 (2), pp. 370-8. Date of Electronic Publication: 2010 Feb 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier, Inc
Original Publication: Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Survivors*, Anthracyclines/*adverse effects , Kidney Neoplasms/*radiotherapy , Radiation Injuries/*epidemiology , Wilms Tumor/*therapy, Adolescent ; Adult ; Bone and Bones/radiation effects ; Cardiovascular System/drug effects ; Cardiovascular System/radiation effects ; Child ; Child, Preschool ; Epidemiologic Factors ; Fertility/radiation effects ; Humans ; Infant ; Kidney/radiation effects ; Kidney Neoplasms/mortality ; Lung/radiation effects ; Neoplasms, Radiation-Induced/epidemiology ; Neoplasms, Second Primary/epidemiology ; Radiation Injuries/classification ; Radiation Injuries/mortality ; Radiotherapy Dosage ; Severity of Illness Index ; Wilms Tumor/mortality ; Young Adult
مستخلص: Purpose: To evaluate the prevalence and severity of adverse events (AEs) and treatment-related risk factors in long-term Wilms' tumor (WT) survivors, with special attention to radiotherapy.
Methods and Materials: The single-center study cohort consisted of 185 WT survivors treated between 1966 and 1996, who survived at least 5 years after diagnosis. All survivors were invited to a late-effects clinic for medical assessment of AEs. AEs were graded for severity in a standardized manner. Detailed radiotherapy data enabled us to calculate the equivalent dose in 2 Gy fractions (EQD(2)) to compare radiation doses in a uniform way. Risk factors were evaluated with multivariate logistic regression analysis.
Results: Medical follow-up was complete for 98% of survivors (median follow-up, 18.9 years; median attained age, 22.9 years); 123 survivors had 462 AEs, of which 392 had Grade 1 or 2 events. Radiotherapy to flank/abdomen increased the risk of any AE (OR, 1.08 Gy(-1) [CI, 1.04-1.13]). Furthermore, radiotherapy to flank/abdomen was associated with orthopedic events (OR, 1.09 Gy(-1) [CI, 1.05-1.13]) and second tumors (OR, 1.11 Gy(-1) [CI, 1.03-1.19]). Chest irradiation increased the risk of pulmonary events (OR, 1.14 Gy(-1) [CI, 1.06-1.21]). Both flank/abdominal and chest irradiation were associated with cardiovascular events (OR, 1.05 Gy(-1) [CI, 1.00-1.10], OR, 1.06 Gy(-1) [CI, 1.01-1.12]) and tissue hypoplasia (OR, 1.17 Gy(-1) [CI, 1.10-1.24], OR 1.10 Gy(-1) [CI, 1.03-1.18]).
Conclusion: The majority of AEs, overall as well as in irradiated survivors, were mild to moderate. Nevertheless, the large amount of AEs emphasizes the importance of follow-up programs for WT survivors.
(2010 Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Anthracyclines)
تواريخ الأحداث: Date Created: 20100209 Date Completed: 20100929 Latest Revision: 20100913
رمز التحديث: 20240628
DOI: 10.1016/j.ijrobp.2009.08.016
PMID: 20137867
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-355X
DOI:10.1016/j.ijrobp.2009.08.016