دورية أكاديمية
Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease.
| العنوان: | Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease. |
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| المؤلفون: | Rehaume LM; University of British Columbia, Centre for Microbial Disease & Immunity Research, 2259 Lower Mall, Vancouver, BC, Canada V6T 1Z4., Jouault T, Chamaillard M |
| المصدر: | Trends in immunology [Trends Immunol] 2010 May; Vol. 31 (5), pp. 171-5. Date of Electronic Publication: 2010 Feb 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4981 (Electronic) Linking ISSN: 14714906 NLM ISO Abbreviation: Trends Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Elsevier Science Ltd., c2001- |
| مواضيع طبية MeSH: | Candida/*immunology , Candidiasis/*immunology , Crohn Disease/*immunology, Animals ; Candidiasis/complications ; Crohn Disease/complications ; Crohn Disease/microbiology ; Crohn Disease/physiopathology ; Humans ; Immunity, Innate |
| مستخلص: | Candida albicans is a diploid fungus that colonizes the gastrointestinal tract asymptomatically in a large proportion of the human population, but can cause life-threatening conditions in immunocompromised patients. Recent immunological investigations have revealed the Nod-like receptor pyrin domain-containing protein 3 (NLRP3) to be a cytosolic surveillance mechanism against germinating Candida. These observations point to the idea of a molecular link between Candida and a spectrum of auto-inflammatory diseases. When excessive activation of NLRP3 occurs, it can confer resistance against disseminating Candida infection but might also cause NLRP3-associated periodic syndromes. Alternatively, we propose a pathophysiological model whereby a defective NLRP3-coupled inflammasome can result in enhanced mucosal colonization of granuloma-provoking microorganisms, including C. albicans, precipitating the formation of Crohn's disease-associated inflammatory lesions. (Copyright 2010 Elsevier Ltd. All rights reserved.) |
| معلومات مُعتمدة: | Canada Canadian Institutes of Health Research |
| تواريخ الأحداث: | Date Created: 20100213 Date Completed: 20100729 Latest Revision: 20100503 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.it.2010.01.007 |
| PMID: | 20149741 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1471-4981 |
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| DOI: | 10.1016/j.it.2010.01.007 |