دورية أكاديمية
Stereotactic body radiation therapy (SBRT) and respiratory gating in lung cancer: dosimetric and radiobiological considerations.
| العنوان: | Stereotactic body radiation therapy (SBRT) and respiratory gating in lung cancer: dosimetric and radiobiological considerations. |
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| المؤلفون: | De La Fuente Herman T; Department of Radiation Oncology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Vlachaki MT, Herman TS, Hibbitts K, Stoner JA, Ahmad S |
| المصدر: | Journal of applied clinical medical physics [J Appl Clin Med Phys] 2010 Jan 29; Vol. 11 (1), pp. 3133. Date of Electronic Publication: 2010 Jan 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley on behalf of American Association of Physicists in Medicine Country of Publication: United States NLM ID: 101089176 Publication Model: Electronic Cited Medium: Internet ISSN: 1526-9914 (Electronic) Linking ISSN: 15269914 NLM ISO Abbreviation: J Appl Clin Med Phys Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Malden, MA : Wiley on behalf of American Association of Physicists in Medicine Original Publication: Reston, VA : American College of Medical Physics, c2000- |
| مواضيع طبية MeSH: | Lung Neoplasms/*radiotherapy , Radiotherapy Planning, Computer-Assisted/*standards , Respiratory-Gated Imaging Techniques/*standards, Aged ; Aged, 80 and over ; Algorithms ; Female ; Four-Dimensional Computed Tomography ; Humans ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Radiation Tolerance/physiology ; Radiation Tolerance/radiation effects ; Radiobiology/standards ; Radiotherapy Dosage ; Respiratory Mechanics ; Technology, Radiologic/standards |
| مستخلص: | The purpose of this study was to assess the impact of respiratory gating on tumor and normal tissue dosimetry in patients treated with SBRT for early stage non-small cell lung cancer (NSCLC). Twenty patients with stage I NSCLC were studied. Treatment planning was performed using four-dimensional computed tomography (4D CT) with free breathing (Plan I), near-end inhalation (Plan II), and near-end exhalation (Plan III). The prescription dose was 60 Gy in three fractions. The tumor displacement was most pronounced for lower peripheral lesions (average 7.0 mm, range 4.1-14.3 mm) when compared to upper peripheral (average 2.4mm, range 1.0-5.1 mm) or central lesions (average 2.9 mm, range 1.0-4.1 mm). In this study, the pencil beam convolution (PBC) algorithm with modified Batho power law for tissue heterogeneity was used for dose calculation. There were no significant differences in tumor and normal tissue dosimetry among the three gated plans. Tumor location however, significantly influenced tumor doses because of the necessity of respecting normal tissue constraints of centrally located structures. For plans I, II and III, average doses to central lesions were lower as compared with peripheral lesions by 4.88 Gy, 8.24 Gy and 6.93 Gy for minimum PTV and 0.98, 1.65 and 0.87 Gy for mean PTV dose, respectively. As a result, the mean single fraction equivalent dose (SFED) values were also lower for central compared to peripheral lesions. In addition, central lesions resulted in higher mean doses for lung, esophagus, and ipsilateral bronchus by 1.24, 1.93 and 7.75 Gy, respectively. These results indicate that the tumor location is the most important determinant of dosimetric optimization of SBRT plans. Respiratory gating proved unhelpful in the planning of these patients with severe COPD. |
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| تواريخ الأحداث: | Date Created: 20100218 Date Completed: 20100625 Latest Revision: 20240605 |
| رمز التحديث: | 20240605 |
| مُعرف محوري في PubMed: | PMC5719765 |
| DOI: | 10.1120/jacmp.v11i1.3133 |
| PMID: | 20160698 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1526-9914 |
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| DOI: | 10.1120/jacmp.v11i1.3133 |