دورية أكاديمية
Antioxidant activity of alpha-pyridoin and its derivatives: possible mechanism.
| العنوان: | Antioxidant activity of alpha-pyridoin and its derivatives: possible mechanism. |
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| المؤلفون: | Cheng LX; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China., Jin XL, Teng QF, Chang J, Yao XJ, Dai F, Qian YP, Tang JJ, Li XZ, Zhou B |
| المصدر: | Organic & biomolecular chemistry [Org Biomol Chem] 2010 Mar 07; Vol. 8 (5), pp. 1058-63. Date of Electronic Publication: 2010 Jan 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry, c2003- |
| مواضيع طبية MeSH: | Antioxidants/*chemistry , Antioxidants/*pharmacology , Pyridines/*pharmacology, Antioxidants/chemical synthesis ; Benzhydryl Compounds/metabolism ; Erythrocytes/drug effects ; Hemolysis/drug effects ; Humans ; Oxidation-Reduction ; Pyridines/chemical synthesis ; Structure-Activity Relationship |
| مستخلص: | alpha-Pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) is a unique enediol antioxidant. To explore the detailed antioxidant mechanism of alpha-pyridoin, we synthesized alpha-pyridoin and its 5,5'- or 6,6'-bis-substituted derivatives (2-7) and compared their capacities to scavenge galvinoxyl radical (GO*) and protect human red blood cells (RBCs) from oxidative haemolysis. It was found that the compounds (5 and 6) with a methyl or methoxy group at the 5-position exhibit significantly higher GO*-scavenging and anti-haemolysis activities than other derivatives and vitamin C. Kinetic analysis of the GO*-scavenging reaction and the effect of added base on the reaction rate revealed that in ethyl acetate, the reaction occurs primarily by the direct hydrogen atom transfer (HAT mechanism). However, in ethanol that supports ionization, the kinetics of the process is mostly governed by sequential proton loss electron transfer (SPLET mechanism). |
| المشرفين على المادة: | 0 (2,2'-pyridoin) 0 (Antioxidants) 0 (Benzhydryl Compounds) 0 (Pyridines) W07Q6T5546 (galvinoxyl) |
| تواريخ الأحداث: | Date Created: 20100219 Date Completed: 20100621 Latest Revision: 20121115 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1039/b922673g |
| PMID: | 20165796 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-0539 |
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| DOI: | 10.1039/b922673g |