دورية أكاديمية
Single nucleotide polymorphisms in genes that are associated with a modified response to statin therapy: the Rotterdam Study.
| العنوان: | Single nucleotide polymorphisms in genes that are associated with a modified response to statin therapy: the Rotterdam Study. |
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| المؤلفون: | de Keyser CE; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands., Eijgelsheim M, Hofman A, Sijbrands EJ, Maitland-van der Zee AH, van Duijn CM, Uitterlinden AG, Witteman JC, Ch Stricker BH |
| المصدر: | The pharmacogenomics journal [Pharmacogenomics J] 2011 Feb; Vol. 11 (1), pp. 72-80. Date of Electronic Publication: 2010 Mar 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101083949 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-1150 (Electronic) Linking ISSN: 1470269X NLM ISO Abbreviation: Pharmacogenomics J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Avenet, NJ : Nature Pub. Group, c2001- |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Cholesterol/*blood , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use , Lipid Metabolism/*genetics, Aged ; Cohort Studies ; Female ; Genetic Variation ; Genotype ; Humans ; Linear Models ; Male ; Middle Aged ; Prospective Studies |
| مستخلص: | The objective of this study was to investigate whether common variation in genes involved in lipid metabolism modify the effect of statins on serum total cholesterol concentration. Statin users were identified in the Rotterdam Study, a prospective population-based cohort study of subjects >55 years of age. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in lipid metabolism and total cholesterol response to statin therapy, using linear regression analysis and adjusting for potential confounders. Replication was performed in an independent extended cohort of the Rotterdam Study. Genotype data and total cholesterol concentrations after start of statin therapy were available for 554 newly started statin users. Two SNPs were associated with a significantly higher cholesterol concentration under statin therapy: SNP rs1532624 in the CETP gene (β: 0.141 mmol l(-1), P=0.004 per additional allele) and SNP rs533556 in the APOA1 gene (β: 0.138 mmol l(-1), P=0.005 per additional allele). In the replication sample, only the CETP rs1532624 SNP again showed a significant association. The SNPs were not related to baseline total cholesterol in non-statin users. In conclusion, we found that the CETP rs1532624 polymorphism is associated with cholesterol response to statin therapy in a cohort of elderly subjects in the general population. |
| التعليقات: | Comment in: Pharmacogenomics. 2011 Jun;12(6):773-8. (PMID: 21692611) |
| المشرفين على المادة: | 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 20100303 Date Completed: 20110510 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1038/tpj.2010.11 |
| PMID: | 20195290 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-1150 |
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| DOI: | 10.1038/tpj.2010.11 |