دورية أكاديمية
أعرض في EDS

Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: an animal model of resistance to epilepsy.

التفاصيل البيبلوغرافية
العنوان: Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: an animal model of resistance to epilepsy.
المؤلفون: Araujo BH; Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. bruno.araujo@neuro.epm.br, Torres LB, Cossa AC, Naffah-Mazzacoratti Mda G, Cavalheiro EA
المصدر: Brain research [Brain Res] 2010 Jun 04; Vol. 1335, pp. 35-40. Date of Electronic Publication: 2010 Mar 17.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Epilepsy/*metabolism , Hippocampus/*metabolism , Receptor, Cannabinoid, CB1/*metabolism, Animals ; CA1 Region, Hippocampal/anatomy & histology ; CA1 Region, Hippocampal/chemistry ; CA1 Region, Hippocampal/metabolism ; CA3 Region, Hippocampal/anatomy & histology ; CA3 Region, Hippocampal/chemistry ; CA3 Region, Hippocampal/metabolism ; Disease Models, Animal ; Epilepsy/immunology ; Epilepsy/physiopathology ; Genetic Predisposition to Disease/genetics ; Hippocampus/anatomy & histology ; Hippocampus/chemistry ; Immunity, Innate/genetics ; Male ; Rats ; Rats, Wistar ; Rodentia ; South America ; Species Specificity
مستخلص: Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 receptor in the hippocampal formation of Proechimys using immunohistochemistry and Western blotting techniques. Results were compared with values obtained from adult Wistar rats. The immunoreactivity for CB1 was evident throughout the Ammon's horn and in the hilar region of both animal species. However, the distribution of these receptors was higher in the stratum lucidum of CA3 and in the hilar region of Proechimys. In addition, higher expression of CB1 receptors was observed in the Proechimys hippocampus. These data could explain, at least partially, the natural resistance of this animal species to developing spontaneous seizures following epileptogenic precipitating events.
(Copyright 2010 Elsevier B.V. All rights reserved.)
المشرفين على المادة: 0 (Receptor, Cannabinoid, CB1)
تواريخ الأحداث: Date Created: 20100323 Date Completed: 20101213 Latest Revision: 20100521
رمز التحديث: 20240628
DOI: 10.1016/j.brainres.2010.03.031
PMID: 20302850
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6240
DOI:10.1016/j.brainres.2010.03.031