دورية أكاديمية
[Therapeutic effect of prostaglandin E1 on diabetic nephropathy: a one-year follow-up study].
| العنوان: | [Therapeutic effect of prostaglandin E1 on diabetic nephropathy: a one-year follow-up study]. |
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| المؤلفون: | Li PF; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. lpf966@163.com, Mu YR, Xin Y, Qu Y, Liao L |
| المصدر: | Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2010 Mar; Vol. 30 (3), pp. 482-5. |
| نوع المنشور: | English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Nanfang yi ke da xue xue bao bian ji bu Country of Publication: China NLM ID: 101266132 Publication Model: Print Cited Medium: Print ISSN: 1673-4254 (Print) Linking ISSN: 16734254 NLM ISO Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Guangzhou : Nanfang yi ke da xue xue bao bian ji bu, 2005- |
| مواضيع طبية MeSH: | Alprostadil/*therapeutic use , Angiotensin-Converting Enzyme Inhibitors/*therapeutic use , Diabetic Nephropathies/*drug therapy, Adult ; Aged ; Albuminuria/urine ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged |
| مستخلص: | Objective: To investigate the therapeutic effect of prostaglandin E1 (PGEl) on diabetic nephropathy (DN) after a one-year treatment. Methods: According to Mogensen DN diagnostic criteria, the patients were divided into DN stages III, IV and V groups. Patients in stage IV nephropathy were subdivided into three groups according to the proteinuria, namely early stage IV (protienuria less than 1.5 g/day), mid-stage IV (protienuria between 1.5 and 2.5 g/day) and late stage IV (protienuria above 2.5 g/day). The patients were randomly given PGEl, PGEl plus angiotensin-converting enzyme inhibitor (ACEI), ACEI mono-therapy or basal treatment (control group). Proteinuria and albuminuria were measured before and at 15 days and 1 year of the treatment. Results: In the patients in DN stages III and early stage IV, proteinuria and albuminuria decreased significantly after 15 days and 1 year of treatment with PGEl+ACEI and PGEl (P<0.01), and the decrements were greater than that in patients receiving ACEI only (P<0.01 or P<0.05). In the patients in mid- and late stage IV nephropathy, proteinuria and albuminuria decreased significantly in PGEl+ACEI group after 15 days and 1 year of treatment (P<0.01), showing greater decrement than in ACEI group (P<0.01 ). Proteinuria and albuminuria decreased significantly in PGEl group after 15 days of treatment (P<0.01), but remained higher than that in ACEI group at one year (P<0.05). In the patients with stage V nephropathy, significant proteinuria and albuminuria reduction occurred in PGEl+ACEI and PGEl groups at 15 days (P<0.01) with a greater decrement than that in ACEI group (P<0.01 or P<0.05). In PGEl+ACEI group, proteinuria and albuminuria showed no significant changes at one year but were lower than those in ACEI group (P<0.05). Proteinuria and albuminuria increased significantly in ACEI and PGEl group after the treatment but were comparable between the two groups (P<0.05). Conclusions: The therapeutic effects are much better in patients with stage III nephropathy than in those in stage V. The combination of PGEl and ACEI produces stronger therapeutic effects than PGE1 or ACEI alone even at the one-year follow up. |
| المشرفين على المادة: | 0 (Angiotensin-Converting Enzyme Inhibitors) F5TD010360 (Alprostadil) |
| تواريخ الأحداث: | Date Created: 20100326 Date Completed: 20110922 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 20335115 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1673-4254 |
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