دورية أكاديمية
Long-term dietary supplementation with a yang-invigorating Chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice.
| العنوان: | Long-term dietary supplementation with a yang-invigorating Chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice. |
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| المؤلفون: | Ko KM; Department of Biochemistry, the Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China., Chiu PY, Leung HY, Siu AH, Chen N, Leong EP, Poon MK |
| المصدر: | Rejuvenation research [Rejuvenation Res] 2010 Apr-Jun; Vol. 13 (2-3), pp. 168-71. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Inc Country of Publication: United States NLM ID: 101213381 Publication Model: Print Cited Medium: Internet ISSN: 1557-8577 (Electronic) Linking ISSN: 15491684 NLM ISO Abbreviation: Rejuvenation Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Larchmont, NY : Mary Ann Liebert Inc., c2004- |
| مواضيع طبية MeSH: | Dietary Supplements*, Aging/*metabolism , Antioxidants/*physiology , Drugs, Chinese Herbal/*therapeutic use , Longevity/*drug effects , Mitochondria/*metabolism , Yang Deficiency/*drug therapy, Aging/drug effects ; Animal Feed ; Animals ; Antioxidants/metabolism ; Drug Evaluation, Preclinical ; Female ; Longevity/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Survival Analysis ; Time Factors ; Yang Deficiency/mortality ; Yang Deficiency/pathology ; Yin-Yang |
| مستخلص: | To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increased median lifespans of both male and female mice as compared to controls. Survival enhancement was associated with protection against age-associated impairments in mitochondrial antioxidant status and functional ability in various tissues. In conclusion, VI-28 could retard the aging process in mice, probably by mitigating age-associated declines in mitochondrial antioxidant status and functional ability in tissues. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Drugs, Chinese Herbal) 0 (VI-28 herbal formula) |
| تواريخ الأحداث: | Date Created: 20100408 Date Completed: 20100810 Latest Revision: 20100513 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1089/rej.2009.0893 |
| PMID: | 20370440 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-8577 |
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| DOI: | 10.1089/rej.2009.0893 |