دورية أكاديمية
The incidence of raised procoagulant factors and hyperhomocysteinaemia in Chinese patients with chronic venous insufficiency.
| العنوان: | The incidence of raised procoagulant factors and hyperhomocysteinaemia in Chinese patients with chronic venous insufficiency. |
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| المؤلفون: | Darvall KA; Department of Vascular Surgery, Heart of England NHS Trust, Birmingham University, Birmingham, UK. katydarvall@btinternet.com, Sam RC, Adam DJ, Silverman SH, Fegan CD, Bradbury AW |
| المصدر: | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery [Eur J Vasc Endovasc Surg] 2010 Aug; Vol. 40 (2), pp. 260-6. Date of Electronic Publication: 2010 Apr 24. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9512728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2165 (Electronic) Linking ISSN: 10785884 NLM ISO Abbreviation: Eur J Vasc Endovasc Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002-: London : Elsevier Original Publication: London, UK : W.B. Saunders Co. Ltd., c1995- |
| مواضيع طبية MeSH: | Blood Coagulation Factors/*analysis , Hyperhomocysteinemia/*ethnology , Venous Insufficiency/*ethnology , Venous Thromboembolism/*ethnology, Adult ; Aged ; Aged, 80 and over ; Asian People/statistics & numerical data ; Chronic Disease ; Comorbidity ; Factor IX/analysis ; Factor VIII/analysis ; Factor XI/analysis ; Female ; Homocysteine/blood ; Hong Kong/epidemiology ; Humans ; Hyperhomocysteinemia/blood ; Male ; Middle Aged ; United Kingdom/epidemiology ; White People/statistics & numerical data |
| مستخلص: | Background: For reasons that are poorly understood, there appear to be differences in the prevalence of chronic venous insufficiency (CVI) and venous thromboembolism between Caucasians and Asians. Objectives: To compare levels of procoagulant factors and homocysteine (Hcy) in Hong Kong (HK) Chinese and United Kingdom (UK) Caucasian populations of patients with CVI (patients of CEAP clinical stages C4 - C6). Methods: HK Chinese and UK Caucasian patients with CEAP clinical grade 4-6 venous disease were enrolled. Patients with conditions known to be associated with thrombophilia (TP) were excluded. UK and HK patients were matched by gender, age (within 5 years) and by CEAP clinical grade. All subjects underwent clinical examination, venous duplex ultrasound, and measurement of Hcy and factors (F) VIII, IX and XI. Results: 63 Patients were enrolled in each group: Mean age 64y (HK group); 67y (UK group). 37% were female; 19% had active venous ulceration. One-third of patients in each group had deep venous reflux. High Hcy, FIX and FXI were significantly more common in the UK group. Multiple TP was more common in the UK group: raised levels of >or=2 factors in 26 vs. 14 patients (P = 0.022, chi(2)). Median Hcy (14.3 vs. 10.8 micromol/L; P < 0.0005, Wilcoxon signed rank [WSR]), FIX (131 vs. 115%; P = 0.048), and FXI (114 vs. 97%; P = 0.002) were significantly higher in the UK group. There was no significant difference in FVIII levels. Conclusions: Raised procoagulant factors were more common in Caucasians compared with Chinese patients with CVI in this study. As with the inherited thrombophilias, the pattern of raised procoagulant factors in Chinese patients appears to differ from that in Caucasians. (Copyright (c) 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Blood Coagulation Factors) 0LVT1QZ0BA (Homocysteine) 9001-27-8 (Factor VIII) 9001-28-9 (Factor IX) 9013-55-2 (Factor XI) |
| تواريخ الأحداث: | Date Created: 20100512 Date Completed: 20100916 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ejvs.2010.02.024 |
| PMID: | 20456987 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2165 |
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| DOI: | 10.1016/j.ejvs.2010.02.024 |