دورية أكاديمية
[Cardioprotective effect of N-stearoylethanolamine under the anaphylactic shock in guinea pigs].
| العنوان: | [Cardioprotective effect of N-stearoylethanolamine under the anaphylactic shock in guinea pigs]. |
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| المؤلفون: | Gulaia NM, Berdyshev AG, Chumak AA, Meged' EF, Kindruk NL, Gorid'ko TN |
| المصدر: | Biomeditsinskaia khimiia [Biomed Khim] 2009 Nov-Dec; Vol. 55 (6), pp. 743-9. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk Country of Publication: Russia (Federation) NLM ID: 101196966 Publication Model: Print Cited Medium: Print ISSN: 2310-6972 (Print) Linking ISSN: 23106905 NLM ISO Abbreviation: Biomed Khim Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk, 2003- |
| مواضيع طبية MeSH: | Anaphylaxis/*prevention & control , Cardiotonic Agents/*pharmacology , Ethanolamines/*pharmacology , Stearic Acids/*pharmacology, Anaphylaxis/metabolism ; Animals ; Guinea Pigs ; Histamine/metabolism ; Male ; Myocytes, Cardiac/metabolism ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Oxidoreductases/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism |
| مستخلص: | It was shown for the first time that endogenous cannabimimetic compound N-stearoylethanolamine (NSE) administered at the dose 65 mg/kg of body weight during two weeks before anaphylaxis had cardioprotective properties on the model of anaphylactic shock in the guinea pigs. NSE reliably normalized the content of histamine and nitric oxide, decreased the activity both inducible and constitutive NO-synthases, prevented accumulation of thiobarbituric acid reactive substances (TBARS) and normalized the activity of catalase, superoxide dismutase and glutathione peroxidase in cardiomyocytes of animals under anaphylaxis. About of 70% of the NSE-treated animals survived under the anaphylactic shock. The present work indicates that NSE may influence the allergic reaction of immediate type and can possibly be used for design of a new type of antiallergic preparations and cardioprotective preparations as well. |
| المشرفين على المادة: | 0 (Cardiotonic Agents) 0 (Ethanolamines) 0 (N-stearoylethanolamine) 0 (Stearic Acids) 0 (Thiobarbituric Acid Reactive Substances) 31C4KY9ESH (Nitric Oxide) 820484N8I3 (Histamine) EC 1.- (Oxidoreductases) EC 1.14.13.39 (Nitric Oxide Synthase) |
| تواريخ الأحداث: | Date Created: 20100518 Date Completed: 20100608 Latest Revision: 20140401 |
| رمز التحديث: | 20221213 |
| PMID: | 20469722 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2310-6972 |
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