دورية أكاديمية
Hyperpolarized 13carbon MR.
| العنوان: | Hyperpolarized 13carbon MR. |
|---|---|
| المؤلفون: | Rowland IJ; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53792, USA. irowland@wisc.edu, Peterson ET, Gordon JW, Fain SB |
| المصدر: | Current pharmaceutical biotechnology [Curr Pharm Biotechnol] 2010 Sep 01; Vol. 11 (6), pp. 709-19. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 100960530 Publication Model: Print Cited Medium: Internet ISSN: 1873-4316 (Electronic) Linking ISSN: 13892010 NLM ISO Abbreviation: Curr Pharm Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hilversum, Netherlands ; Boca Raton, FL : Bentham Science Publishers, c2000- |
| مواضيع طبية MeSH: | Carbon Isotopes* , Molecular Probe Techniques* , Molecular Probes*, Image Enhancement/*methods , Magnetic Resonance Imaging/*methods , Molecular Imaging/*methods, Radiopharmaceuticals |
| مستخلص: | Hyperpolarized (HP) (13)C labeled compounds can be used as MR contrast agents to investigate metabolic pathways in vivo in almost real time. To date, a high proportion of reported studies have utilized HP 1-(13)C pyruvate to investigate intracellular metabolism in tumors and other tissues. The long T(1) relaxation time of the carboxylate carbon enables the (13)C signal of the pyruvate to be followed for nearly 2 minutes following injection. During this time, pyruvate is rapidly metabolized to generate observable metabolites such as alanine and lactate. HP (13)C labeled compounds have, for example, also been used to non-invasively probe physiological parameters such as pH, which emphasizes the expanding potential of the technique. The commercial availability of dynamic nuclear polarization (DNP) systems to generate hyperpolarized material for injection has made the technique available to researchers worldwide. As a consequence, DNP (13)C MR has become a rapidly expanding area of research. The technique, with its specific strengths and weaknesses, has incredible potential coupled with inherent limitations, and this review aims to both present background to the technique and describe some of the necessary hardware and software essential to perform hyperpolarized (13)C studies. An overview of the current and future role of HP (13)C based molecular imaging is presented. |
| المشرفين على المادة: | 0 (Carbon Isotopes) 0 (Molecular Probes) 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20100526 Date Completed: 20110110 Latest Revision: 20190917 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/138920110792246636 |
| PMID: | 20497107 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-4316 |
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| DOI: | 10.2174/138920110792246636 |