دورية أكاديمية
The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition.
| العنوان: | The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. |
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| المؤلفون: | Lacruz RS; School of Dentistry, Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA., Nanci A, White SN, Wen X, Wang H, Zalzal SF, Luong VQ, Schuetter VL, Conti PS, Kurtz I, Paine ML |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 2010 Aug 06; Vol. 285 (32), pp. 24432-8. Date of Electronic Publication: 2010 Jun 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Sodium-Bicarbonate Symporters/*metabolism , Tooth/*embryology, Animals ; Hydrogen-Ion Concentration ; Kidney Tubules/metabolism ; Mice ; Mice, Transgenic ; Microscopy, Electron, Scanning/methods ; Models, Biological ; Mutation ; Phenotype ; Reverse Transcriptase Polymerase Chain Reaction ; Sodium/chemistry ; Sodium-Bicarbonate Symporters/chemistry ; X-Ray Microtomography/methods |
| مستخلص: | Proximal renal tubular acidosis (pRTA) is a syndrome caused by abnormal proximal tubule reabsorption of bicarbonate resulting in metabolic acidosis. Patients with mutations to the SLC4A4 gene (coding for the sodium bicarbonate cotransporter NBCe1), have pRTA, growth delay, ocular defects, and enamel abnormalities. In an earlier report, we provided the first evidence that enamel cells, the ameloblasts, express NBCe1 in a polarized fashion, thereby contributing to trans-cellular bicarbonate transport. To determine whether NBCe1 plays a critical role in enamel development, we studied the expression of NBCe1 at various stages of enamel formation in wild-type mice and characterized the biophysical properties of enamel in NBCe1(-/-) animals. The enamel of NBCe1(-/-) animals was extremely hypomineralized and weak with an abnormal prismatic architecture. The expression profile of amelogenin, a known enamel-specific gene, was not altered in NBCe1(-/-) animals. Our results show for the first time that NBCe1 expression is required for the development of normal enamel. This study provides a mechanistic model to account for enamel abnormalities in certain patients with pRTA. |
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| معلومات مُعتمدة: | Canada CAPMC CIHR; R01 DK077162 United States DK NIDDK NIH HHS; S10RR019253 United States RR NCRR NIH HHS; S10 RR019253 United States RR NCRR NIH HHS; R01 DE019629 United States DE NIDCR NIH HHS; R01 DK058563 United States DK NIDDK NIH HHS; DK077162 United States DK NIDDK NIH HHS; DE013404 United States DE NIDCR NIH HHS; R01 DE013404 United States DE NIDCR NIH HHS; DE019629 United States DE NIDCR NIH HHS; DK058563 United States DK NIDDK NIH HHS |
| المشرفين على المادة: | 0 (Sodium-Bicarbonate Symporters) 9NEZ333N27 (Sodium) |
| تواريخ الأحداث: | Date Created: 20100610 Date Completed: 20100920 Latest Revision: 20220224 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC2915679 |
| DOI: | 10.1074/jbc.M110.115188 |
| PMID: | 20529845 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1083-351X |
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| DOI: | 10.1074/jbc.M110.115188 |