دورية أكاديمية
The immunohistochemical profile of Spitz nevi and conventional (non-Spitzoid) melanomas: a baseline study.
| العنوان: | The immunohistochemical profile of Spitz nevi and conventional (non-Spitzoid) melanomas: a baseline study. |
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| المؤلفون: | Garrido-Ruiz MC; Department of Pathology, 12 de Octubre University Hospital, Madrid, Spain., Requena L, Ortiz P, Pérez-Gómez B, Alonso SR, Peralto JL |
| المصدر: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2010 Sep; Vol. 23 (9), pp. 1215-24. Date of Electronic Publication: 2010 Jun 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 8806605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0285 (Electronic) Linking ISSN: 08933952 NLM ISO Abbreviation: Mod Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Inc. Original Publication: Baltimore, MD : Williams & Wilkins, c1988- |
| مواضيع طبية MeSH: | Biomarkers, Tumor/*analysis , Melanoma/*diagnosis , Nevus, Epithelioid and Spindle Cell/*diagnosis , Skin Neoplasms/*diagnosis, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Male ; Melanoma/metabolism ; Middle Aged ; Nevus, Epithelioid and Spindle Cell/metabolism ; Skin Neoplasms/metabolism ; Tissue Array Analysis ; Young Adult |
| مستخلص: | Several isolated markers have been proposed to aid in differential diagnostic of difficult melanocytic lesions, albeit none has been shown to be definitive in differentiating Spitz nevus from melanoma. This study proposes a wide panel of 22 markers having important functions in different biological functions (cell cycle, apoptosis, DNA repair proteins and membranous receptors) to provide a combination of proteins associated with either benign or malignant phenotype. Using tissue microarrays, we compared protein expression profiles in 28 typical Spitz nevi and 62 primary vertical growth phase non-spitzoid melanomas. Most of the significant differences were linked to cell-cycle deregulation such as overexpression of cyclin D1 and p21 in Spitz nevi compared with non-spitzoid melanomas (74 vs 16% and 91 vs 27%, respectively) and mitotic rate including Ki-67, highly expressed in deep areas of non-spitzoid melanomas (37%), whereas it is not expressed in Spitz nevi (0%), topoisomerase IIalpha (79% in non-spitzoid melanomas vs 15% in Spitz nevi) and nuclear survivin (69% in melanomas vs 0% in Spitz nevi). A combination of biological markers differentially expressed in Spitz nevi from non-spitzoid melanomas is defined, thus providing a potential tool for histopathological differential diagnostic between Spitz nevus and melanoma. Nevertheless, more studies including atypical Spitz nevi and spitzoid melanomas are necessary to further establish a reliable panel to differentiate among difficult cases. |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) |
| تواريخ الأحداث: | Date Created: 20100615 Date Completed: 20110103 Latest Revision: 20230210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1038/modpathol.2010.102 |
| PMID: | 20543820 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1530-0285 |
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| DOI: | 10.1038/modpathol.2010.102 |