دورية أكاديمية
[O-aminoazotoluene inhibits DENA-induced hepatocarcinogenesis when used together in mice].
| العنوان: | [O-aminoazotoluene inhibits DENA-induced hepatocarcinogenesis when used together in mice]. |
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| المؤلفون: | Kaledin VI, Il'nitskaia SI, Baginskaia NV |
| المصدر: | Voprosy onkologii [Vopr Onkol] 2010; Vol. 56 (2), pp. 196-200. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Nauchno-issledovatelʹskiĭ institut onkologii im. N.N. Petrova Country of Publication: Russia (Federation) NLM ID: 0413775 Publication Model: Print Cited Medium: Print ISSN: 0507-3758 (Print) Linking ISSN: 05073758 NLM ISO Abbreviation: Vopr Onkol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013-: St Petersburg : Nauchno-issledovatelʹskiĭ institut onkologii im. N.N. Petrova Original Publication: St Petersburg : Izdatelstvo Meditsina, Leningradskoe Otdelenie |
| مواضيع طبية MeSH: | Anticarcinogenic Agents/*pharmacology , Carcinogens/*antagonists & inhibitors , Diethylnitrosamine/*antagonists & inhibitors , Liver Neoplasms, Experimental/*prevention & control , Lung Neoplasms/*prevention & control , o-Aminoazotoluene/*pharmacology, Animals ; Anticarcinogenic Agents/administration & dosage ; Drug Administration Schedule ; Liver Neoplasms, Experimental/chemically induced ; Liver Neoplasms, Experimental/pathology ; Lung Neoplasms/chemically induced ; Lung Neoplasms/pathology ; Male ; Mice ; Mice, Inbred CBA ; Mice, Inbred ICR ; Neoplasms, Experimental/prevention & control ; Time Factors ; o-Aminoazotoluene/administration & dosage |
| مستخلص: | When used separately, diethylnitrosamine (DENA) initiates 4-6 times more neoplastic lesions in the liver of suckling mice than ortho-aminoazotoluene (OAT) lower. However, after combined treatment with either carcinogen the total number of hepatic lesions was significantly than that in mice injected with DENA only. Similar inhibition of DENA-induced hepatocarcinogenesis was observed when OAT was administered 8-12 hrs after DENA. Our findings cannot be adequately explained except by competition of the carcinogens for supposedly target molecules of protein origin, presumably, transcription factors, which contribute to generation of genetic information. They have different affinities for different compounds and, therefore, suffer different damage from the latter functioning. |
| المشرفين على المادة: | 0 (Anticarcinogenic Agents) 0 (Carcinogens) 3IQ78TTX1A (Diethylnitrosamine) QHZ900P7ZA (o-Aminoazotoluene) |
| تواريخ الأحداث: | Date Created: 20100618 Date Completed: 20100708 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| PMID: | 20552897 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0507-3758 |
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