دورية أكاديمية
Clonal origin of emerging populations of Ehrlichia ruminantium in Burkina Faso.
| العنوان: | Clonal origin of emerging populations of Ehrlichia ruminantium in Burkina Faso. |
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| المؤلفون: | Adakal H; CIRDES Laboratoire de Biotechnologie (URBIO), 559, 3-51 Avenue du Gouverneur Louveau, B.P. 454, Bobo-Dioulasso, Burkina Faso, France. hassaneadakal@yahoo.fr, Gavotte L, Stachurski F, Konkobo M, Henri H, Zoungrana S, Huber K, Vachiery N, Martinez D, Morand S, Frutos R |
| المصدر: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2010 Oct; Vol. 10 (7), pp. 903-12. Date of Electronic Publication: 2010 May 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Evolution, Molecular*, Ehrlichia ruminantium/*genetics, Animals ; Burkina Faso/epidemiology ; Ehrlichia ruminantium/physiology ; Haplotypes ; Ixodidae/microbiology ; Linkage Disequilibrium ; Polymorphism, Genetic ; Recombination, Genetic |
| مستخلص: | Cowdriosis or heartwater is a major tick-borne disease on ruminants in Africa and the Caribbean. The causative agent is Ehrlichia ruminantium, an intracellular bacterium. Development of vaccines against heartwater has been hampered the limited efficiency of vaccine in the field, thought to be a consequence of the high genetic diversity of strains circulating in a same area. A sampling scheme was set to collect ticks over 2 years in a delimited area and well identified flock. Prevalence was low at about 3%. A set of 37 strains was considered for MLST analysis along with two reference strains, i.e. ERGA and ERWO, for which full-length genome was available, using a previously described scheme based on the genes gltA, groEL, lepA, lipA, lipB, secY, sodB and sucA. Two populations were identified both with limited genetic variability but with differing evolutionary patterns. Population 1 is in genomic stasis, in agreement with the paradigm for intracellular bacteria. The two reference strains, one from the Caribbean separated from West African strains three centuries ago and another one isolated in South Africa, belong to Population 1. Population 2 is on expansion following a recent clonal emergence from Population 1. The founder strain was identified as strain 395. Strain 623 displays a particularly high rate of mutations in groEL. Owing to the chaperone function of GroEL, this might indicate another clonal emergence under way. This work brings further insight in the genomic plasticity of E. ruminantium and its impact on vaccine strategy. (Copyright 2010 Elsevier B.V. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20100618 Date Completed: 20110302 Latest Revision: 20100903 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.meegid.2010.05.011 |
| PMID: | 20553966 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-7257 |
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| DOI: | 10.1016/j.meegid.2010.05.011 |