دورية أكاديمية
Effects of raloxifene treatment on the phenotype of blood monocytes.
| العنوان: | Effects of raloxifene treatment on the phenotype of blood monocytes. |
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| المؤلفون: | Boudjeltia KZ; Experimental Medicine Laboratory, ULB 222 Unit, Université Libre de Bruxelles, Intercommunale de santé publique du pays de Charleroi, CHU de Charleroi, Hôpital André Vésale, 6110 Montigny-Le-Tilleul, Belgium. karim.zouaoui@chu-charleroi.be, Durez P, Oberweis D, Guillaume M, Remacle C, Cauchie P, Vanhaeverbeek M, Brohée D, Ducobu J, Gregoir C |
| المصدر: | Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2010 May; Vol. 88 (5), pp. 601-5. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Ottawa, ON : Canadian Science Publishing Original Publication: Ottawa, National Research Council of Canada. |
| مواضيع طبية MeSH: | Coronary Disease/*prevention & control , Fibrinolysis/*drug effects , Monocytes/*drug effects , Postmenopause/*drug effects , Raloxifene Hydrochloride/*therapeutic use , Selective Estrogen Receptor Modulators/*therapeutic use, Aged ; Cholesterol/blood ; Cholesterol, HDL/blood ; Coronary Disease/blood ; Cytokines/biosynthesis ; Cytokines/blood ; Female ; Flow Cytometry ; Humans ; L-Selectin/biosynthesis ; L-Selectin/blood ; Leukocyte Count ; Lipopolysaccharide Receptors/biosynthesis ; Lipopolysaccharide Receptors/blood ; Lipoprotein(a)/blood ; Middle Aged ; Monocytes/immunology ; Monocytes/metabolism ; Postmenopause/blood ; Raloxifene Hydrochloride/administration & dosage ; Raloxifene Hydrochloride/pharmacology ; Selective Estrogen Receptor Modulators/administration & dosage ; Selective Estrogen Receptor Modulators/pharmacology |
| مستخلص: | Raloxifene (RLX), a selective oestrogen receptor modulator, has oestrogen-agonist effects on bone, lipoproteins, and homocysteine and oestrogen-antagonist activity in the breast and uterus, positioning it as a potential drug for long-term prevention of coronary heart disease in postmenopausal women. To further evaluate its influence on cardiovascular risk factors, we studied the effects of 60 mg/day RLX on serum lipid levels, inflammatory (high-sensitivity C-reactive protein, and coagulation (fibrinogen) markers, monocytes, and fibrinolysis in 15 healthy postmenopausal women. Markers were measured at baseline, after 1 month without treatment, and after 3 months of treatment. Fibrinolysis was evaluated using the euglobulin clot lysis time (ECLT) determined with a new semiautomatic optical method. Monocyte phenotype was determined by measurement of the expression of the antigens CD14, HLA-DR, and CD62-L using flow cytometry. After 3 months of RLX treatment, we observed a decrease in total cholesterol (p = 0.002), in low-density lipoprotein cholesterol (p <0.001), and in lipoprotein A (p = 0.01). Fibrinogen (p = 0.002) decreased significantly, and high-sensitivity C-reactive protein had a tendency to decrease, but this did not reach statistical significance (p = 0.06). RLX treatment had no effect on ECLT (p = 0.223) or on white blood cell, lymphocyte, and total monocyte counts (p = 0.313). Monocyte expression of HLA-DR, CD14, and CD62-L was not modified by the treatment. In conclusion, we confirm that RLX has beneficial short-term effects on levels of lipids and inflammatory markers, with no effect on fibrinolysis or monocyte phenotype. |
| المشرفين على المادة: | 0 (Cholesterol, HDL) 0 (Cytokines) 0 (Lipopolysaccharide Receptors) 0 (Lipoprotein(a)) 0 (Selective Estrogen Receptor Modulators) 126880-86-2 (L-Selectin) 4F86W47BR6 (Raloxifene Hydrochloride) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 20100618 Date Completed: 20101022 Latest Revision: 20171116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1139/y10-002 |
| PMID: | 20555430 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1205-7541 |
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| DOI: | 10.1139/y10-002 |