تقرير
Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus nonagenarians.
| العنوان: | Outcomes of thrombolysis for acute ischemic stroke in octogenarians versus nonagenarians. |
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| المؤلفون: | Mateen FJ, Buchan AM, Hill MD |
| مؤلفون مشاركون: | CASES Investigators |
| المصدر: | Stroke [Stroke] 2010 Aug; Vol. 41 (8), pp. 1833-5. Date of Electronic Publication: 2010 Jun 24. |
| نوع المنشور: | Comparative Study; Letter |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins Original Publication: Dallas : American Heart Association |
| مواضيع طبية MeSH: | Brain Ischemia/*drug therapy , Stroke/*drug therapy , Tissue Plasminogen Activator/*therapeutic use, Age Factors ; Aged, 80 and over ; Canada ; Female ; Fibrinolytic Agents/therapeutic use ; Humans ; Male ; Registries ; Thrombolytic Therapy/methods ; Treatment Outcome |
| مستخلص: | Background and Purpose: Little is reported on the outcomes of nonagenarians who are treated with intravenous tissue plasminogen activator for acute ischemic stroke. It is uncertain whether nonagenarians have higher mortality and worse functional outcomes than octogenarians. Methods: All patients who were >or=80 years of age were extracted from the Canadian Activase for Stroke Effectiveness Study national registry, a 60-center Canadian acute ischemic stroke treatment network. Patients were divided into 2 groups: those who were 80 to 89 years of age (octogenarians) and those who were 90 to 99 years of age (nonagenarians), and compared by baseline clinical, demographic, treatment, and outcome-related measures. Results: Twenty-eight nonagenarians and 242 octogenarians were treated with intravenous tissue plasminogen activator for acute ischemic stroke over the 2.5-year observation period. Nonagenarians and octogenarians did not differ on any of the baseline clinical or demographic variables. Both groups were predominantly female (77% nonagenarians and 61% octogenarians), hypertensive (54% and 60%), and predominantly had severe strokes (National Institutes of Health Stroke Scale score >15; 58% and 52%). The rate of symptomatic intracerebral hemorrhage (7% nonagenarians versus 4% octogenarians; P=0.359), 90-day mortality (52% versus 33%; P=0.087), and 30-day favorable functional outcomes ([modified Rankin score |
| المشرفين على المادة: | 0 (Fibrinolytic Agents) EC 3.4.21.68 (Tissue Plasminogen Activator) |
| تواريخ الأحداث: | Date Created: 20100626 Date Completed: 20100817 Latest Revision: 20161122 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1161/STROKEAHA.110.586438 |
| PMID: | 20576948 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4628 |
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| DOI: | 10.1161/STROKEAHA.110.586438 |