دورية أكاديمية
African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I.
| العنوان: | African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I. |
|---|---|
| المؤلفون: | Feller G; Ben Gurion University of the Negev, Bioinformatic Core Facility, National Institute of Biotechnology in the Negev, Beer Sheva, Israel., Kugel A, Moonshine D, Chalifa-Caspi V, Scholz M, Prüfer D, Rabinski T, Müller KJ, Ofir R |
| المصدر: | Planta medica [Planta Med] 2010 Nov; Vol. 76 (16), pp. 1847-51. Date of Electronic Publication: 2010 Jun 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0221 (Electronic) Linking ISSN: 00320943 NLM ISO Abbreviation: Planta Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart ; New York : George Thieme Original Publication: Stuttgart, Hippokrates Verlag. |
| مواضيع طبية MeSH: | Phytotherapy* , Polymorphism, Single Nucleotide*, Black People/*genetics , Neoplasms/*genetics , Oleanolic Acid/*analogs & derivatives , Saponins/*therapeutic use , White People/*genetics, Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Line, Tumor ; Growth Inhibitors/pharmacology ; Growth Inhibitors/therapeutic use ; Humans ; Lymphocyte Activation/genetics ; Mice ; Neoplasms/drug therapy ; Nigella/chemistry ; Oleanolic Acid/pharmacology ; Oleanolic Acid/therapeutic use ; Pharmacogenetics ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Saponins/pharmacology ; Seeds |
| مستخلص: | α-Hederin, a natural triterpene saponin and its derivative kalopanaxsaponin I (ksI) exhibit cytotoxicity against various cancer cell lines and IN VIVO tumors. We studied the genetic variants contributing to the activity of these two anticancer compounds. Cell lines derived from 30 trios of European descent (Centre d'Etude du Polymorphisme Human, CEPH; CEU) and 30 trios of African descent (Yoruban, YRI) were used. Cytotoxicity was determined as inhibition of cell growth at increasing concentrations of α-hederin or ksI for 24 h. In comparison to the European, the Yoruban populations revealed a higher sensitivity to α-hederin and to ksI that can be attributed to several unique SNPs. These SNPs are located near 111 and 130 genes in the European and the Yoruban populations, respectively, raising the possibility that some of these genes contribute to the differential sensitivity to these compounds. (© Georg Thieme Verlag KG Stuttgart · New York.) |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Growth Inhibitors) 0 (Plant Extracts) 0 (Saponins) 0 (beta-hederin) 0 (kalopanax saponin I) 6SMK8R7TGJ (Oleanolic Acid) |
| تواريخ الأحداث: | Date Created: 20100626 Date Completed: 20110502 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1055/s-0030-1250061 |
| PMID: | 20577945 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-0221 |
|---|---|
| DOI: | 10.1055/s-0030-1250061 |