دورية أكاديمية
أعرض في EDS

Considerations in using US-based laboratory toxicity tables to evaluate laboratory toxicities among healthy malawian and Ugandan infants.

التفاصيل البيبلوغرافية
العنوان: Considerations in using US-based laboratory toxicity tables to evaluate laboratory toxicities among healthy malawian and Ugandan infants.
المؤلفون: Lubega IR; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda. ilubega@mujhu.org, Fowler MG, Musoke PM, Elbireer A, Bagenda D, Kafulafula G, Ko J, Mipando L, Mubiru M, Kumwenda N, Taha T, Jackson JB, Guay L
المصدر: Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2010 Sep; Vol. 55 (1), pp. 58-64.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999-
مواضيع طبية MeSH: Blood Chemical Analysis*, HIV Infections/*epidemiology , HIV Infections/*pathology, Cross-Sectional Studies ; Female ; Hematologic Tests/methods ; Humans ; Infant ; Infant, Newborn ; Malawi/epidemiology ; Male ; Uganda/epidemiology ; United States/epidemiology
مستخلص: Objectives: To determine normal hematologic and selected blood chemistry values among healthy, full-term, non-HIV-exposed infants in Uganda and Malawi, and to determine the proportion of healthy babies with an apparent laboratory toxicity based on Division of AIDS toxicity tables.
Design: This was a cross-sectional laboratory study of infants from birth to 6 months of age.
Methods: Blood samples were collected from a total of 561 infants and analyzed according to age categories similar to those in the 2004 Division of AIDS toxicity tables. Select chemistry and hematology parameters were determined and values compared with those in the toxicity tables.
Results: In the first 56 days of life, there were few graded toxicities except for neutropenia in 2 of 10 (20%) Ugandan and 13 of 45 (29%) Malawian infants at birth. After 7 days, about 20% of the infants in Uganda and Malawi would have been classified as having a neutropenia whereas 47% and 53% of those more than 2 months of age in Uganda and Malawi respectively, would have been reported as having an abnormal hemoglobin. Chemistry findings were not different from US norms.
Conclusions: These findings underscore the importance of establishing relevant local laboratory norms for infants.
References: J Clin Pathol. 1996 Aug;49(8):664-6. (PMID: 8881919)
East Afr Med J. 1995 Jan;72(1):10-4. (PMID: 7781547)
Trop Med Int Health. 2006 Nov;11(11):1741-8. (PMID: 17054755)
J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):460-3. (PMID: 16810112)
J Pediatr. 1997 Jan;130(1):77-85. (PMID: 9003854)
Clin Diagn Lab Immunol. 2004 Jan;11(1):29-34. (PMID: 14715541)
J Lab Clin Med. 1999 Jan;133(1):15-22. (PMID: 10385477)
Blut. 1985 Jul;51(1):11-8. (PMID: 3848333)
Ann Trop Paediatr. 2004 Dec;24(4):301-9. (PMID: 15720887)
Ann Trop Paediatr. 2006 Sep;26(3):169-79. (PMID: 16925953)
World Health Stat Q. 1997;50(3-4):199-209. (PMID: 9477550)
S Afr Med J. 1968 May 4;42(18):444-50. (PMID: 5655372)
Haematologia (Budap). 1988;21(1):57-63. (PMID: 3396976)
J Int Assoc Physicians AIDS Care (Chic). 2005 Jul;4(3):73-6. (PMID: 16867975)
J Acquir Immune Defic Syndr. 2007 Dec 1;46(4):426-32. (PMID: 17786129)
AIDS. 2002 Apr 12;16(6):851-8. (PMID: 11919486)
J Acquir Immune Defic Syndr. 2003 Aug 15;33(5):635-41. (PMID: 12902809)
معلومات مُعتمدة: U01 AI46749 United States AI NIAID NIH HHS; HHSN267200800001G United States DK NIDDK NIH HHS; U01 AI068632 United States AI NIAID NIH HHS; UM1 AI068632 United States AI NIAID NIH HHS; U01 AI068632-03 United States AI NIAID NIH HHS; U01 AI046749 United States AI NIAID NIH HHS; U01 AI048054 United States AI NIAID NIH HHS; U01 AI068616 United States AI NIAID NIH HHS; HHSN267200800001C United States HD NICHD NIH HHS; U01 AI041110 United States AI NIAID NIH HHS; U01 AI48054 United States AI NIAID NIH HHS; AI068632 United States AI NIAID NIH HHS; 1 U01 AI068616 United States AI NIAID NIH HHS; 5 U01 AI41110 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20100701 Date Completed: 20100916 Latest Revision: 20211020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3033212
DOI: 10.1097/QAI.0b013e3181db059d
PMID: 20588184
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-7884
DOI:10.1097/QAI.0b013e3181db059d