دورية أكاديمية
أعرض في EDS

CD137 is required for M cell functional maturation but not lineage commitment.

التفاصيل البيبلوغرافية
العنوان: CD137 is required for M cell functional maturation but not lineage commitment.
المؤلفون: Hsieh EH; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA., Fernandez X, Wang J, Hamer M, Calvillo S, Croft M, Kwon BS, Lo DD
المصدر: The American journal of pathology [Am J Pathol] 2010 Aug; Vol. 177 (2), pp. 666-76. Date of Electronic Publication: 2010 Jul 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011-: New York : Elsevier
Original Publication: Philadelphia [etc.] American Assn. of Pathologists [etc.]
مواضيع طبية MeSH: Cell Lineage*, Lymphoid Tissue/*cytology , Peyer's Patches/*cytology , Tumor Necrosis Factor Receptor Superfamily, Member 9/*immunology, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Caco-2 Cells ; Cell Differentiation/immunology ; Cell Line ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Humans ; Intestinal Mucosa/cytology ; Lymphoid Tissue/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Nasopharynx/anatomy & histology ; Peyer's Patches/immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 9/genetics ; Tumor Necrosis Factor-alpha/immunology
مستخلص: Mucosal immune surveillance depends on M cells that reside in the epithelium overlying Peyer's patch and nasopharyngeal associated lymphoid tissue to transport particles to underlying lymphocytes. M cell development is associated with B lymphocytes in a basolateral pocket, but the interactions between these cells are poorly understood. In a cell culture model of M cell differentiation, we found lymphotoxin/tumor necrosis factor alpha induction of CD137 (TNFRSF9) protein on intestinal epithelial cell lines, raising the possibility that CD137 on M cells in vivo might interact with CD137L expressed by B cells. Accordingly, while CD137-deficient mice produced UEA-1+ M cell progenitors in nasopharyngeal associated lymphoid tissue and Peyer's patch epithelium, they showed an abnormal morphology, including the absence of basolateral B cell pockets. More important, CD137-deficient nasopharyngeal associated lymphoid tissue M cells were defective in microparticle transcytosis. Bone marrow irradiation chimeras confirmed that while induction of UEA-1+ putative M cell precursors was not CD137-dependent, full M cell transcytosis function required expression of CD137 by radioresistant stromal cells as well as by bone marrow-derived cells. These results are consistent with a two-step model of M cell differentiation, with initial CD137-independent commitment to the M cell lineage followed by a CD137-CD137L interaction of M cells with CD137-activated B lymphocytes or dendritic cells for functional maturation.
References: Int Immunol. 2004 Jan;16(1):91-9. (PMID: 14688064)
Nat Immunol. 2001 Nov;2(11):1004-9. (PMID: 11685223)
Immunol Rev. 2003 Oct;195:5-14. (PMID: 12969306)
J Immunol. 2002 Jun 1;168(11):5483-90. (PMID: 12023342)
Biochem Biophys Res Commun. 2000 Dec 29;279(3):808-13. (PMID: 11162433)
Clin Vaccine Immunol. 2009 Mar;16(3):397-407. (PMID: 19129472)
Nature. 1995 Feb 9;373(6514):531-6. (PMID: 7845467)
DNA Res. 2005;12(2):127-37. (PMID: 16303744)
J Immunol. 2002 Nov 1;169(9):4882-8. (PMID: 12391199)
J Control Release. 2005 Nov 2;108(1):56-62. (PMID: 16091298)
J Immunol. 2006 Oct 1;177(7):4464-72. (PMID: 16982882)
Infect Immun. 2005 Aug;73(8):5144-51. (PMID: 16041031)
FASEB J. 2007 Feb;21(2):456-63. (PMID: 17167064)
J Immunol. 2004 Sep 15;173(6):4218-29. (PMID: 15356173)
J Biol Chem. 1997 Mar 7;272(10):6448-56. (PMID: 9045669)
Microbes Infect. 2000 Jul;2(9):1119-24. (PMID: 10967292)
J Control Release. 2010 Mar 3;142(2):196-205. (PMID: 19896996)
Immunol Rev. 2005 Aug;206:177-89. (PMID: 16048549)
Int Immunol. 2002 Mar;14(3):275-86. (PMID: 11867564)
Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10360-4. (PMID: 1279676)
Gastroenterology. 2005 Jul;129(1):321-7. (PMID: 16012957)
J Pathol. 2006 Jun;209(2):240-9. (PMID: 16552796)
Science. 1999 Dec 3;286(5446):1965-8. (PMID: 10583962)
Am J Pathol. 2008 Mar;172(3):671-80. (PMID: 18258848)
J Immunol. 2005 Jun 1;174(11):6803-8. (PMID: 15905521)
J Exp Med. 1996 Apr 1;183(4):1461-72. (PMID: 8666904)
Nat Rev Immunol. 2003 Apr;3(4):292-303. (PMID: 12669020)
Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G273-84. (PMID: 18556421)
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5548-52. (PMID: 103096)
J Immunol. 2009 Nov 1;183(9):5738-47. (PMID: 19828638)
J Immunol. 2004 Jul 1;173(1):86-91. (PMID: 15210762)
Tissue Antigens. 2007 Dec;70(6):470-9. (PMID: 17990986)
J Exp Med. 2004 Sep 20;200(6):783-95. (PMID: 15381731)
J Biol Chem. 2008 Nov 7;283(45):30585-95. (PMID: 18782762)
Gastroenterology. 2004 Jul;127(1):213-23. (PMID: 15236187)
J Immunol. 2008 Jun 15;180(12):7840-6. (PMID: 18523247)
Am J Pathol. 2005 Jun;166(6):1647-54. (PMID: 15920150)
J Histochem Cytochem. 1997 Oct;45(10):1341-50. (PMID: 9313796)
Science. 1997 Aug 15;277(5328):949-52. (PMID: 9252325)
Immunol Rev. 2008 Jun;223:186-201. (PMID: 18613837)
Cell Immunol. 2003 Jul;224(1):8-16. (PMID: 14572796)
EMBO J. 2003 Jan 2;22(1):121-30. (PMID: 12505990)
Eur J Immunol. 2008 Jun;38(6):1598-609. (PMID: 18421790)
Cytokine. 2009 Jul;47(1):69-76. (PMID: 19501526)
J Cell Sci. 1993 Jun;105 ( Pt 2):445-60. (PMID: 8408276)
Immunity. 1997 Apr;6(4):491-500. (PMID: 9133428)
J Leukoc Biol. 2007 Sep;82(3):638-44. (PMID: 17550973)
معلومات مُعتمدة: R21 AI073689 United States AI NIAID NIH HHS; AI63426 United States AI NIAID NIH HHS; R01 AI042944 United States AI NIAID NIH HHS; AI42944 United States AI NIAID NIH HHS; AI73689 United States AI NIAID NIH HHS; P01 AI089624 United States AI NIAID NIH HHS; R01 AI063426 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Tumor Necrosis Factor Receptor Superfamily, Member 9)
0 (Tumor Necrosis Factor-alpha)
تواريخ الأحداث: Date Created: 20100710 Date Completed: 20110125 Latest Revision: 20220316
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC2913358
DOI: 10.2353/ajpath.2010.090811
PMID: 20616340
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-2191
DOI:10.2353/ajpath.2010.090811