دورية أكاديمية
Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain.
| العنوان: | Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain. |
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| المؤلفون: | Gomes da Silva S; Department of Physiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. sergio.gomes@unifesp.br, Araujo BH, Cossa AC, Scorza FA, Cavalheiro EA, Naffah-Mazzacoratti Mda G, Arida RM |
| المصدر: | Neurochemistry international [Neurochem Int] 2010 Nov; Vol. 57 (5), pp. 492-6. Date of Electronic Publication: 2010 Jul 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 8006959 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9754 (Electronic) Linking ISSN: 01970186 NLM ISO Abbreviation: Neurochem Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford [Elmsford, N. Y.] Pergamon Press. |
| مواضيع طبية MeSH: | Brain Chemistry/*physiology , Physical Conditioning, Animal/*physiology , Receptor, Cannabinoid, CB1/*biosynthesis, Aging/physiology ; Animals ; Blotting, Western ; Body Weight/physiology ; Brain/growth & development ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/metabolism ; Corpus Striatum/anatomy & histology ; Corpus Striatum/metabolism ; Hippocampus/anatomy & histology ; Hippocampus/metabolism ; Immunohistochemistry ; Male ; Rats ; Rats, Wistar |
| مستخلص: | Accumulating evidence indicates that the endocannabinoid system plays an essential role in the development and maturation of the central nervous system. Studies also have demonstrated that neural systems that regulate behavioral responses can be influenced by exercise during development. Exercise and endogenous cannabinoid activity have independently been shown to regulate brain plasticity, hence demonstrating a promising field of the endocannabinoid-exercise interaction. In order to investigate whether physical exercise during development would promote changes the brain endocannabinoid system, we investigated the cannabinoid receptor type 1 (CB1) expression in the brain of rats trained during the adolescent period. The results showed that an aerobic exercise program performed during adolescence significantly reduced the CB1 receptor expression in the striatum and hippocampal formation. These findings suggest an important link between the endocannabinoid system and physical training in adolescence. (Copyright 2010 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Receptor, Cannabinoid, CB1) |
| تواريخ الأحداث: | Date Created: 20100713 Date Completed: 20101222 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.neuint.2010.07.001 |
| PMID: | 20621146 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-9754 |
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| DOI: | 10.1016/j.neuint.2010.07.001 |