دورية أكاديمية
NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies.
| العنوان: | NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies. |
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| المؤلفون: | Weide T; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla CA 92037, USA., Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV |
| المصدر: | ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Jul 08; Vol. 1 (4), pp. 150-154. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: Print Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society |
| مستخلص: | Metallo-ß-lactamases (MBL) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 ß-lactamase is the most commonly encountered MBL in clinical isolates worldwide. Described here are potent and selective small molecule inhibitors of VIM-2 containing the arylsulfonyl-NH-1,2,3-triazole chemotype that potentiate the efficacy of the ß-lactam, imipenem, in E. coli. |
| References: | Clin Microbiol Rev. 2005 Apr;18(2):306-25. (PMID: 15831827) N Engl J Med. 2005 Jan 27;352(4):380-91. (PMID: 15673804) Bioorg Med Chem. 2006 Apr 15;14(8):2627-35. (PMID: 16378729) Int J Antimicrob Agents. 2007 Apr;29(4):380-8. (PMID: 17223319) Biol Pharm Bull. 2004 Jun;27(6):851-6. (PMID: 15187432) Bioorg Med Chem. 2009 Jul 15;17(14):5027-37. (PMID: 19553129) Biochem Pharmacol. 2007 Dec 15;74(12):1686-701. (PMID: 17597585) J Antimicrob Chemother. 2003 Feb;51(2):257-66. (PMID: 12562689) BMC Evol Biol. 2008 Oct 02;8:270. (PMID: 18831750) Ann Med. 2003;35(4):226-34. (PMID: 12846264) |
| معلومات مُعتمدة: | R21 NS059451-01S1 United States NS NINDS NIH HHS; R01 GM087620-01 United States GM NIGMS NIH HHS; R21 NS059451 United States NS NINDS NIH HHS; R21 NS059451-01 United States NS NINDS NIH HHS; R01 GM087620 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20100714 Latest Revision: 20211020 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC2901175 |
| DOI: | 10.1021/ml900022q |
| PMID: | 20625539 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1948-5875 |
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| DOI: | 10.1021/ml900022q |