دورية أكاديمية
[Relationship of tumor necrosis factor gene polymorphism and acute graft-versus-host disease after unrelated allogeneic hematopoietic stem cell transplantation].
| العنوان: | [Relationship of tumor necrosis factor gene polymorphism and acute graft-versus-host disease after unrelated allogeneic hematopoietic stem cell transplantation]. |
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| المؤلفون: | Jin L; Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China., Xiao HW, Lai XY, Wu GQ, Luo Y, Shi JM, Tan YM, Huang H |
| المصدر: | Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2010 Apr; Vol. 49 (4), pp. 320-4. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 16210490R Publication Model: Print Cited Medium: Print ISSN: 0578-1426 (Print) Linking ISSN: 05781426 NLM ISO Abbreviation: Zhonghua Nei Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Beijing : Zhonghua yi xue hui Nei ke xue hui |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Graft vs Host Disease/*genetics , Hematopoietic Stem Cell Transplantation/*adverse effects , Lymphotoxin-alpha/*genetics , Tumor Necrosis Factor-alpha/*genetics, Adolescent ; Adult ; Child ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Tissue Donors ; Transplantation, Homologous ; Young Adult |
| مستخلص: | Objective: To explore the relationship between tumor necrosis factor (TNF) gene polymorphisms in donors and recipients and the incidence and severity of acute graft-versus-host diseases (aGVHD) after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Single nucleotide polymorphisms (SNPs) of TNFalpha-238 (G/A), TNFalpha-857 (C/T), TNFalpha-863 (C/A), TNFalpha-1031 (T/C), TNFbeta + 252(A/G) were analyzed by Multiplex SNaPshot analysis in 76 pairs of donors and recipients. Results: Transplantation involving donors with TNFalpha-857 CC genotype resulted in a higher incidence of grade II-IV aGVHD than donors with CT genotype (91.3% vs 8.7%, P = 0.039). In the 23 patients with grade II-IV aGVHD, no patients had TNFbeta + 252 AA genotype, 19 (82.6%) had GA genotype and 4 (17.4%) had GG genotype. There was a significant difference in the distribution pattern of the TNFbeta + 252 (AA, GA and GG) genotypes in these patients (P = 0.03). There was no significant association of TNFalpha-238 (G/A), TNFalpha-863 (C/A) and TNFalpha-1031(T/C) polymorphisms with the risk of aGVHD. Conclusion: These results suggest donor TNFalpha-857 CC genotype is related to a higher incidence of grade II-IV aGVHD, and patients with TNFbeta + 252 AA genotype have protection against the risk of grade II-IV aGVHD. |
| المشرفين على المادة: | 0 (Lymphotoxin-alpha) 0 (Tumor Necrosis Factor-alpha) |
| تواريخ الأحداث: | Date Created: 20100715 Date Completed: 20100902 Latest Revision: 20140226 |
| رمز التحديث: | 20231215 |
| PMID: | 20627040 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0578-1426 |
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