دورية أكاديمية
A prospective cohort study of dengue infection in schoolchildren in Long Xuyen, Viet Nam.
| العنوان: | A prospective cohort study of dengue infection in schoolchildren in Long Xuyen, Viet Nam. |
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| المؤلفون: | Tien NT; Pasteur Institute Ho Chi Minh City, 167 Pasteur Street, District 3, Ho Chi Minh City, Viet Nam., Luxemburger C, Toan NT, Pollissard-Gadroy L, Huong VT, Van Be P, Rang NN, Wartel TA, Lang J |
| المصدر: | Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2010 Sep; Vol. 104 (9), pp. 592-600. Date of Electronic Publication: 2010 Jul 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7506129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3503 (Electronic) Linking ISSN: 00359203 NLM ISO Abbreviation: Trans R Soc Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2013- : Oxford : Oxford University Press Original Publication: 1920- : London : Royal Society of Tropical Medicine and Hygiene |
| مواضيع طبية MeSH: | Dengue Virus*/immunology, Dengue/*epidemiology, Adolescent ; Antibodies, Viral/isolation & purification ; Child ; Child, Preschool ; Dengue/immunology ; Dengue/transmission ; Dengue Vaccines ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Incidence ; Male ; Prospective Studies ; School Health Services/standards ; Vietnam/epidemiology |
| مستخلص: | A dynamic school-based cohort of 2-15 year-olds was established in Long Xuyen, Viet Nam to provide epidemiological data for a dengue vaccine efficacy trial. Active surveillance of febrile episodes identified clinically-suspected dengue and acute and convalescent sera were collected. IgG seroconversion between annual seroprevalence surveys identified sub-clinical infections. In 2004, 2190 children were enrolled with 3239, 3146, and 3081 present each year from 2005 to 2007 consecutively. In all, 627 children had a total of 690 clinically-suspected dengue episodes (394 hospitalisations, 296 outpatients) with 284-310 (41.2-45.0%) laboratory-confirmed depending on testing. Dengue serotype 2 was predominant in 2004 and 2005, and serotype 1 in 2006 and 2007. The acute dengue disease incidence rate per 1000 person-years ranged from 16.9 in 2005 to 40.4 in 2007. The average annual incidence of primary dengue infection (IgG seroconversion in previously naïve children) was 11.4% and the symptomatic to asymptomatic primary infection ratio ranged from 1:3-1:6. Study withdrawal rate, a feasibility indicator for conducting efficacy trials, was low: 4.2% per year when excluding children who changed schools. Our 2004-2007 results confirm the high transmission of dengue in children in Long Xuyen and demonstrate the suitability of this study site for a large scale efficacy trial. (Copyright 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Dengue Vaccines) |
| تواريخ الأحداث: | Date Created: 20100716 Date Completed: 20110224 Latest Revision: 20100816 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.trstmh.2010.06.003 |
| PMID: | 20630553 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-3503 |
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| DOI: | 10.1016/j.trstmh.2010.06.003 |