دورية أكاديمية
Molecular signatures of thyroid follicular neoplasia.
| العنوان: | Molecular signatures of thyroid follicular neoplasia. |
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| المؤلفون: | Borup R; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark., Rossing M, Henao R, Yamamoto Y, Krogdahl A, Godballe C, Winther O, Kiss K, Christensen L, Høgdall E, Bennedbaek F, Nielsen FC |
| المصدر: | Endocrine-related cancer [Endocr Relat Cancer] 2010 Jul 28; Vol. 17 (3), pp. 691-708. Date of Electronic Publication: 2010 Jul 28 (Print Publication: 2010). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 9436481 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1479-6821 (Electronic) Linking ISSN: 13510088 NLM ISO Abbreviation: Endocr Relat Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Woodlands, Almondsbury, Bristol, UK : Published for the Society of Endocrinology by the Journal of Endocrinology Ltd., 1994- |
| مواضيع طبية MeSH: | Gene Expression Profiling*, Adenocarcinoma, Follicular/*metabolism , Adenoma/*metabolism , Biomarkers, Tumor/*metabolism , Thyroid Neoplasms/*metabolism, Adenocarcinoma, Follicular/genetics ; Adenocarcinoma, Follicular/pathology ; Adenoma/genetics ; Adenoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Cell Proliferation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Middle Aged ; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics ; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism ; Oligonucleotide Array Sequence Analysis ; Prognosis ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism ; Receptors, Thyroid Hormone/genetics ; Receptors, Thyroid Hormone/metabolism ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Young Adult |
| مستخلص: | The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid carcinoma (FC) and normofollicular adenoma (FA) as well as fetal/microFA (fetal adenoma). Carcinomas were strongly enriched in transcripts encoding proteins involved in DNA replication and mitosis corresponding to increased number of proliferating cells and depleted number of transcripts encoding factors involved in growth arrest and apoptosis. In the latter group, the combined loss of transcripts encoding the nuclear orphan receptors NR4A1 and NR4A3, which were recently shown to play a causal role in hematopoetic neoplasia, was noteworthy. The analysis of differentially expressed transcripts provided a mechanism for cancer progression, which is why we exploited the results in order to generate a molecular classifier that could identify 95% of all carcinomas. Validation employing public domain and cross-platform data demonstrated that the signature was robust and could diagnose follicular nodules originating from different geographical locations and platforms with similar accuracy. We came to the conclusion that down-regulation of factors involved in growth arrest and apoptosis may represent a decisive step in the pathogenesis of FC. Moreover, the described molecular pathways provide an accurate and robust genetic signature for the diagnosis of FA and FC. |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (DNA-Binding Proteins) 0 (NR4A3 protein, human) 0 (Nuclear Receptor Subfamily 4, Group A, Member 1) 0 (Receptors, Steroid) 0 (Receptors, Thyroid Hormone) |
| تواريخ الأحداث: | Date Created: 20100730 Date Completed: 20101112 Latest Revision: 20151119 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1677/ERC-09-0288 |
| PMID: | 20668010 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1479-6821 |
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| DOI: | 10.1677/ERC-09-0288 |