دورية أكاديمية
Synthesis of novel tetrahydroisoquinoline bronchodilators.
| العنوان: | Synthesis of novel tetrahydroisoquinoline bronchodilators. |
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| المؤلفون: | Dalence-Guzmán MF; Respiratorius AB, Magistratsvägen 10, SE 226 43 Lund, Sweden., Toftered J, Oltner VT, Wensbo D, Johansson MH |
| المصدر: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Sep 01; Vol. 20 (17), pp. 4999-5003. Date of Electronic Publication: 2010 Jul 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | Bronchodilator Agents/*chemical synthesis , Isoquinolines/*chemical synthesis, Bronchi/drug effects ; Bronchodilator Agents/chemistry ; Bronchodilator Agents/pharmacology ; Humans ; In Vitro Techniques ; Isoquinolines/chemistry ; Isoquinolines/pharmacology ; Structure-Activity Relationship |
| مستخلص: | The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide 71 was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of pulmonary disorders. (Copyright 2010 Elsevier Ltd. All rights reserved.) |
| المشرفين على المادة: | 0 (Bronchodilator Agents) 0 (Isoquinolines) |
| تواريخ الأحداث: | Date Created: 20100804 Date Completed: 20101206 Latest Revision: 20141120 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bmcl.2010.07.057 |
| PMID: | 20678935 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3405 |
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| DOI: | 10.1016/j.bmcl.2010.07.057 |