دورية أكاديمية
Seizures during pregnancy modify the development of hippocampal interneurons of the offspring.
| العنوان: | Seizures during pregnancy modify the development of hippocampal interneurons of the offspring. |
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| المؤلفون: | do Vale TG; Disciplina de Neurologia Experimental, Universidade Federal de São Paulo, São Paulo, Brasil., da Silva AV, Lima DC, de Lima E, Torres LB, Cossa AC, de Oliveira EM, Cabral FR, Cavalheiro EA, Naffah-Mazzacoratti Mda G, Amado D |
| المصدر: | Epilepsy & behavior : E&B [Epilepsy Behav] 2010 Sep; Vol. 19 (1), pp. 20-5. Date of Electronic Publication: 2010 Aug 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Diego, CA : Academic Press, c2000- |
| مواضيع طبية MeSH: | Hippocampus/*growth & development , Hippocampus/*pathology , Interneurons/*pathology , Prenatal Exposure Delayed Effects/*pathology , Seizures/*pathology, Age Factors ; Animals ; Animals, Newborn ; Calcium-Binding Proteins/metabolism ; Cell Count/methods ; Disease Models, Animal ; Female ; Male ; Phosphopyruvate Hydratase/metabolism ; Pilocarpine ; Pregnancy ; Prenatal Exposure Delayed Effects/physiopathology ; Rats ; Rats, Wistar ; Seizures/chemically induced |
| مستخلص: | We investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calcium-binding proteins in the offspring. Female Wistar rats were submitted to the pilocarpine model and mated during the chronic period. Seizure frequency was monitored over the entire pregnancy. Pups were perfused at postnatal days 6 and 13, and the brains processed for Nissl staining and immunohistochemistry for NeuN, calbindin, calretinin, and parvalbumin. Number of stained cells in the hippocampus was estimated through stereological methods. Our results showed a decrease in epileptic seizure frequency during pregnancy. No differences were observed in NeuN-positive, CR-positive cells, and Nissl-stained hippocampal neurons between the groups. However, there was a significant decrease in calbindin-positive cells (P=0.005) and a significant increase in parvalbumin-positive cells (P=0.02) in the experimental group when compared with the control group. These results suggest that seizures during pregnancy affect the development of specific hippocampal interneurons of the offspring. (Copyright © 2010 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Calcium-Binding Proteins) 01MI4Q9DI3 (Pilocarpine) EC 4.2.1.11 (Phosphopyruvate Hydratase) |
| تواريخ الأحداث: | Date Created: 20100817 Date Completed: 20110112 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.yebeh.2010.06.032 |
| PMID: | 20708978 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1525-5069 |
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| DOI: | 10.1016/j.yebeh.2010.06.032 |