دورية أكاديمية
Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil.
| العنوان: | Diagnosis of hantavirus infection in humans and rodents in Ribeirão Preto, State of São Paulo, Brazil. |
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| المؤلفون: | Figueiredo GG; Virology Research Center, School of Medicine of the University of São Paulo, Ribeirão Preto, SP, Brazil., Borges AA, Campos GM, Machado AM, Saggioro FP, Sabino Júnior Gdos S, Badra SJ, Ortiz AA, Figueiredo LT |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2010 Jul-Aug; Vol. 43 (4), pp. 348-54. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: Print Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1997-> : Uberaba, MG, Brazil : Sociedade Brasileira de Medicina Tropical Original Publication: Rio De Janeiro : Sociedade Brasileira De Medicina Tropical |
| مواضيع طبية MeSH: | Disease Reservoirs/*veterinary , Orthohantavirus/*genetics , Hantavirus Pulmonary Syndrome/*diagnosis , Rodent Diseases/*diagnosis, Animals ; Antibodies, Viral/blood ; Brazil/epidemiology ; Enzyme-Linked Immunosorbent Assay ; Female ; Orthohantavirus/classification ; Orthohantavirus/isolation & purification ; Hantavirus Pulmonary Syndrome/mortality ; Hantavirus Pulmonary Syndrome/virology ; Humans ; Male ; Phylogeny ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Alignment |
| مستخلص: | Introduction: Hantavirus pulmonary and cardiovascular syndrome (HPCS) is an emerging serious disease in the Americas. Hantaviruses (Bunyaviridae) are the causative agents of this syndrome and are mainly transmitted through inhalation of aerosols containing the excreta of wild rodents. In the Ribeirão Preto region (state of São Paulo, Brazil), HPCS has been reported since 1998, caused by the Araraquara virus (ARAV), for which Necromys lasiurus is the rodent reservoir. This study aimed to show diagnostic results relating to infection in humans and rodents, obtained at the Virology Research Center of the Ribeirão Preto School of Medicine, University of São Paulo, between 2005 and 2008. Methods: HPCS was diagnosed by means of ELISA and/or RT-PCR in 11 (21.2%) out of 52 suspected cases, and 54.4% of these were fatal. Furthermore, 595 wild rodents (Necromys lasiurus, Akodon sp, Calomys tener and Oligoryzomys sp) were caught between 2005 and 2008. Results: Fifteen (2.5%) of these rodents presented antibodies for hantavirus, as follows: Necromys lasiurus (4%), Calomys tener (1.9%) and Akodon sp (1.5%). Nucleotide sequences obtained through RT-PCR from one HPCS patient and one Calomys tener rodent were compared with hantavirus sequences from GenBank, which showed that both were homologous with ARAV. Conclusions: This work corroborates previous studies showing that ARAV is the hantavirus causing HPCS in the Ribeirão Preto region. It also shows that rodents infected with hantavirus represent a constant risk of transmission of this virus to man. |
| المشرفين على المادة: | 0 (Antibodies, Viral) |
| تواريخ الأحداث: | Date Created: 20100831 Date Completed: 20110404 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/s0037-86822010000400002 |
| PMID: | 20802928 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-9849 |
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| DOI: | 10.1590/s0037-86822010000400002 |