دورية أكاديمية
[Effect of antioxidants lipin and quercetin on indices of lipid peroxidation and antioxidant system in recipients of renal allotransplants].
| العنوان: | [Effect of antioxidants lipin and quercetin on indices of lipid peroxidation and antioxidant system in recipients of renal allotransplants]. |
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| المؤلفون: | Zohrab'ian RO |
| المصدر: | Klinichna khirurhiia [Klin Khir] 2010 Jul (7), pp. 41-4. |
| نوع المنشور: | Clinical Trial; English Abstract; Journal Article |
| اللغة: | Ukrainian |
| بيانات الدورية: | Publisher: Ministerstvo Okhorony Zdorovia Ukrainy Country of Publication: Ukraine NLM ID: 9516872 Publication Model: Print Cited Medium: Print ISSN: 0023-2130 (Print) Linking ISSN: 00232130 NLM ISO Abbreviation: Klin Khir Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Kyiv : Ministerstvo Okhorony Zdorovia Ukrainy Original Publication: Kyïv : [s.n.], c1995- |
| مواضيع طبية MeSH: | Kidney Transplantation*, Antioxidants/*therapeutic use , Graft Rejection/*prevention & control , Lipid Peroxidation/*drug effects , Quercetin/*therapeutic use, Adolescent ; Adult ; Antioxidants/administration & dosage ; Antioxidants/metabolism ; Catalase/blood ; Erythrocytes/drug effects ; Erythrocytes/enzymology ; Erythrocytes/metabolism ; Female ; Graft Rejection/blood ; Graft Rejection/enzymology ; Graft Rejection/metabolism ; Humans ; Male ; Malondialdehyde/blood ; Middle Aged ; Organic Chemicals/administration & dosage ; Organic Chemicals/therapeutic use ; Quercetin/administration & dosage ; Superoxide Dismutase/blood ; Transplantation, Homologous ; Young Adult |
| مستخلص: | Activation of the free-radical oxidation processes (FROP) in the environment of activity inhibition of antioxidant defense system (ADS) plays an important role in pathogenesis of an ischemic-reperfusion damage (IRD) of renal allotransplant (RAT), causes its dysfunction and shortens long-term survival. Along with standard measures there was proposed intraoperative intravenous administration of antioxidant "cocktail", containing preparations lipin and quercetin, to recipient before switching on the kidney into the blood circulation and further during 3-5 days postoperatively. There were studied up the impact of lipin and quercetin on indices of peroxidal oxidation of lipids, and ADS activity of the RAT recipients in early postoperative period. There was established, that these preparations inhibit activity of the FROP, raise the ADS potential in the recipient organism, promoting IRD severity reduction of RAT and acceleration of its function restoration, |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Organic Chemicals) 0 (lipine) 4Y8F71G49Q (Malondialdehyde) 9IKM0I5T1E (Quercetin) EC 1.11.1.6 (Catalase) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20100910 Date Completed: 20101123 Latest Revision: 20161018 |
| رمز التحديث: | 20221213 |
| PMID: | 20825091 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0023-2130 |
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