دورية أكاديمية
Spermatoxic effects of operation sweep herbal supplement in male albino rats.
| العنوان: | Spermatoxic effects of operation sweep herbal supplement in male albino rats. |
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| المؤلفون: | Orisakwe OE; Toxicology Unit, Department of Clinical Pharmacy & Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria. eorish@aol.com, Debem HC, Etuk EU, Elsa AT |
| المصدر: | Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2010; Vol. 21 (2), pp. 147-56. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9101750 Publication Model: Print Cited Medium: Print ISSN: 0792-6855 (Print) Linking ISSN: 07926855 NLM ISO Abbreviation: J Basic Clin Physiol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jun. 2011- : Berlin : Walter de Gruyter Original Publication: London, England : Freund Pub. House, c1990- |
| مواضيع طبية MeSH: | Dietary Supplements/*toxicity , Plant Preparations/*toxicity , Spermatozoa/*drug effects, Animals ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Epididymis/drug effects ; Epididymis/pathology ; Lethal Dose 50 ; Male ; Organ Size/drug effects ; Plant Extracts/chemistry ; Plant Extracts/toxicity ; Plant Preparations/chemistry ; Powders ; Rats ; Rats, Wistar ; Sperm Count ; Sperm Motility/drug effects ; Testis/drug effects ; Testis/pathology |
| مستخلص: | Operation Sweep (OPS) de rheumatism powder is a registered Nigerian poly-herbal medicine. The acute and sub-chronic testicular toxicology of the OPS powder was investigated in male albino rats. The rats, divided into 10 per group, received aqueous extract of the OPS powder, orally, at 0, 0.75, 1.50, 2.25 g/kg for 30 days. Animals were sacrificed on day 30; the testes and epididymis were excised and weighed. The testes were processed for histological analysis, and the epididymis was used for sperm quality: epididymal sperm count (ESC), epididymal sperm motility (ESMot) and the epididymal sperm morphology (ESMor) determination. The results showed a non-significant increase in the body weights of the treated groups. Treatment with OPS caused a significant (p < .05) reduction of the relative weight of the epididymis in the 2.25g/kg dose group; a significant (p < .05) decrease in the ESC and active ESMot, an increase in the dead ESMot, and a nonsignificant (p > .05) effect on the ESMor. Histologic examination of the testes indicated no serous pathological changes except for some mild vascular congestion at 1.5 and 2.25 g/kg. This study suggests that the aqueous extract of the OPS powder may cause epididymal toxicity as shown in the adverse effect on sperm quality. |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Plant Preparations) 0 (Powders) |
| تواريخ الأحداث: | Date Created: 20100922 Date Completed: 20101005 Latest Revision: 20191111 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1515/jbcpp.2010.21.2.147 |
| PMID: | 20853597 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0792-6855 |
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| DOI: | 10.1515/jbcpp.2010.21.2.147 |