دورية أكاديمية
[Changes in protein, lipid composition, DNA- and RNA- polymerase activity of the chromatin fraction and the nuclear matrix of the rat liver in hypovitaminosis E].
| العنوان: | [Changes in protein, lipid composition, DNA- and RNA- polymerase activity of the chromatin fraction and the nuclear matrix of the rat liver in hypovitaminosis E]. |
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| عنوان ترانسليتريتد: | Izmeneniia belkovogo, lipidnogo sostava, DNK- i RNK-polimeraznoĭ aktivnosti fraktsiĭ khromatina i iadernogo matriksa pecheni krys v usloviiakh E-gipovitaminoza. |
| المؤلفون: | Gubskiĭ IuI, Levitskiĭ EL, Chabannyĭ VN, Gol'dshteĭn NB, Kapralov AA, Petrova GV, Donchenko GV, Volkov GL, Litoshenko AIa |
| المصدر: | Ukrainskii biokhimicheskii zhurnal (1978) [Ukr Biokhim Zh (1978)] 1990 Nov-Dec; Vol. 62 (6), pp. 22-30. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Naukova Dumka Country of Publication: Ukraine NLM ID: 7804246 Publication Model: Print Cited Medium: Print ISSN: 0201-8470 (Print) Linking ISSN: 02018470 NLM ISO Abbreviation: Ukr Biokhim Zh (1978) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kiev : Izdatelstvo Naukova Dumka |
| مواضيع طبية MeSH: | Cell Nucleus/*metabolism , Liver/*metabolism , Vitamin E Deficiency/*metabolism, Animals ; Chromatin/metabolism ; DNA-Directed DNA Polymerase/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Female ; Lipid Metabolism ; Nuclear Matrix/metabolism ; Nuclear Proteins/metabolism ; Rats |
| مستخلص: | E-hypovitaminosis-induced antioxidant deficiency in rats causes changes in some properties of nuclear structures of the liver cells, i.e. fractions of transcriptionally active and repressed chromatin and nuclear matrix. Changes are found in the protein spectrum of the fraction of transcriptionally active chromatin and nuclear matrix. Lipids of transcriptionally active and repressed chromatin fractions may be peroxidated when this process is stimulated in the NADPH- and ascorbate-dependent systems. In antioxidant deficiency these processes are intensified in the fractions of repressed chromatin. E-hypovitaminosis leads to changes in the fatty acid spectrum of chromatin fractions which correlated with the shifts in the process of lipid peroxidation. Antioxidant deficiency produces changes in the activities of endogenous DNA- and RNA-polymerases in chromatin fractions and in the nuclear matrix. In the fraction of the transcriptionally active liver chromatin of E-deficient animals the endogenous total DNA-polymerase activity and the activity of DNA-polymerases alpha and beta decrease, while in the fractions of repressed chromatin the total RNA-polymerase activity increases. In E-hypovitaminosis the endogenous DNA- and RNA-polymerase activities in the nuclear matrix decrease. Addition of alpha-tocopherol to the preparations of the isolated nuclear matrix results in an increase of the DNA- and RNA-polymerase activities which is more vivid in preparations made of the E-hypovitaminous animal liver. |
| المشرفين على المادة: | 0 (Chromatin) 0 (Nuclear Proteins) EC 2.7.7.6 (DNA-Directed RNA Polymerases) EC 2.7.7.7 (DNA-Directed DNA Polymerase) |
| تواريخ الأحداث: | Date Created: 19901101 Date Completed: 19910522 Latest Revision: 20150505 |
| رمز التحديث: | 20221213 |
| PMID: | 2087788 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0201-8470 |
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