دورية أكاديمية
أعرض في EDS

Cord blood administration induces oligodendrocyte survival through alterations in gene expression.

التفاصيل البيبلوغرافية
العنوان: Cord blood administration induces oligodendrocyte survival through alterations in gene expression.
المؤلفون: Rowe DD; Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, FL 33612, USA. drowe@health.usf.edu, Leonardo CC, Hall AA, Shahaduzzaman MD, Collier LA, Willing AE, Pennypacker KR
المصدر: Brain research [Brain Res] 2010 Dec 17; Vol. 1366, pp. 172-88. Date of Electronic Publication: 2010 Sep 29.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Fetal Blood/*metabolism , Gene Expression Regulation/*physiology , Oligodendroglia/*physiology, Animals ; Animals, Newborn ; Cell Proliferation ; Cell Survival/physiology ; Cell- and Tissue-Based Therapy/methods ; Cells, Cultured ; Cerebral Cortex/cytology ; Disease Models, Animal ; Gene Expression Profiling/methods ; Glucose/deficiency ; Humans ; Hypoxia ; Infarction, Middle Cerebral Artery/therapy ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; L-Lactate Dehydrogenase/metabolism ; Myelin Proteins/genetics ; Myelin Proteins/metabolism ; O Antigens/metabolism ; Oligodendroglia/drug effects ; Oligonucleotide Array Sequence Analysis/methods ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Versicans/genetics ; Versicans/metabolism
مستخلص: Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white matter tracts in vivo and directly protects mature primary OL cultures from oxygen glucose deprivation (OGD). Microarray studies of RNA prepared from OL cultures subjected to OGD and treated with HUCB cells showed an increase in the expression of 33 genes associated with OL proliferation, survival, and repair functions, such as myelination. The microarray results were verified using quantitative RT-PCR for the following eight genes: U2AF homology motif kinase 1 (Uhmk1), insulin-induced gene 1 (Insig1), metallothionein 3 (Mt3), tetraspanin 2 (Tspan2), peroxiredoxin 4 (Prdx4), stathmin-like 2 (Stmn2), myelin oligodendrocyte glycoprotein (MOG), and versican (Vcan). Immunohistochemistry showed that MOG, Prdx4, Uhmk1, Insig1, and Mt3 protein expression were upregulated in the ipsilateral white matter tracts of rats infused with HUCB cells 48h after middle cerebral artery occlusion (MCAO). Furthermore, promoter region analysis of these genes revealed common transcription factor binding sites, providing insight into the shared signal transduction pathways activated by HUCB cells to enhance transcription of these genes. These results show expression of genes induced by HUCB cell therapy that could confer oligoprotection from ischemia.
(Copyright © 2010 Elsevier B.V. All rights reserved.)
References: Cell. 2004 May 28;117(5):625-35. (PMID: 15163410)
Stroke. 2004 Oct;35(10):2390-5. (PMID: 15322304)
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):741-5. (PMID: 9012855)
FEBS Lett. 2002 Dec 4;532(1-2):67-9. (PMID: 12459464)
J Biol Chem. 1986 Aug 5;261(22):10282-9. (PMID: 3015924)
Neurobiol Dis. 2008 Dec;32(3):486-98. (PMID: 18930139)
J Cell Sci. 2006 Nov 1;119(Pt 21):4381-9. (PMID: 17074832)
Ann N Y Acad Sci. 2005 May;1049:67-83. (PMID: 15965108)
Brain Res. 2002 Mar 8;929(2):252-60. (PMID: 11864631)
Neurochem Res. 1998 Mar;23(3):319-28. (PMID: 9482244)
J Leukoc Biol. 2008 Aug;84(2):519-28. (PMID: 18495781)
J Neurochem. 1999 Dec;73(6):2600-8. (PMID: 10582623)
Dev Biol. 1981 Apr 30;83(2):328-38. (PMID: 6786943)
J Biol Chem. 2004 Feb 27;279(9):8316-24. (PMID: 14583632)
Neurosci Lett. 1982 Apr 16;29(2):183-8. (PMID: 6178060)
Toxicol Appl Pharmacol. 2008 Sep 15;231(3):318-27. (PMID: 18554677)
Biol Chem. 2002 Mar-Apr;383(3-4):347-64. (PMID: 12033427)
Physiol Rev. 2001 Apr;81(2):871-927. (PMID: 11274346)
Glia. 2008 Jul;56(9):954-62. (PMID: 18383345)
Cell. 1996 Feb 23;84(4):623-31. (PMID: 8598048)
Neurosci Res. 2002 Aug;43(4):323-33. (PMID: 12135776)
J Cereb Blood Flow Metab. 1998 May;18(5):521-30. (PMID: 9591844)
J Biol Chem. 2007 Sep 14;282(37):27436-27446. (PMID: 17635920)
Development. 1993 May;118(1):283-95. (PMID: 8375338)
Int J Cancer. 2008 Apr 1;122(7):1521-9. (PMID: 18027847)
J Neurosci. 2003 Jun 15;23(12):4967-74. (PMID: 12832519)
Cell Metab. 2006 Jan;3(1):15-24. (PMID: 16399501)
J Cereb Blood Flow Metab. 2003 Mar;23(3):263-74. (PMID: 12621301)
Circulation. 2009 Jan 27;119(3):480-6. (PMID: 19171871)
J Cell Biol. 1980 Jun;85(3):890-902. (PMID: 6248568)
Spine (Phila Pa 1976). 2010 Jul 15;35(16):1520-6. (PMID: 20581748)
Exp Hematol. 2007 Jul;35(7):1119-31. (PMID: 17588481)
Cell Transplant. 2006;15(3):213-23. (PMID: 16719056)
Leuk Res. 2008 Sep;32(9):1358-65. (PMID: 18384876)
J Neurochem. 1999 Jan;72(1):1-9. (PMID: 9886048)
Immunology. 2009 Feb;126(2):220-32. (PMID: 18624725)
Biochem Biophys Res Commun. 2008 Sep 12;374(1):64-8. (PMID: 18611392)
Circ Res. 2000 Apr 28;86(8):892-6. (PMID: 10785512)
Stem Cells Dev. 2005 Oct;14(5):576-86. (PMID: 16305342)
Mol Biol Cell. 2005 Mar;16(3):1330-40. (PMID: 15635104)
J Neurosci Res. 1991 Feb;28(2):244-53. (PMID: 1851850)
Trends Mol Med. 2005 Dec;11(12):571-8. (PMID: 16290020)
J Neurosci Res. 1995 Oct 15;42(3):335-42. (PMID: 8583501)
Oncogene. 2006 Jun 15;25(25):3565-75. (PMID: 16462766)
Neurosci Biobehav Rev. 1997 Mar;21(2):151-66. (PMID: 9062938)
Amino Acids. 2008 Feb;34(2):175-85. (PMID: 17177074)
FEBS Lett. 2007 Aug 7;581(20):3863-8. (PMID: 17644091)
Glia. 1998 Apr;22(4):371-8. (PMID: 9517569)
Neuropathol Appl Neurobiol. 1980 Mar-Apr;6(2):119-32. (PMID: 7374914)
Glia. 1996 Jun;17(2):83-93. (PMID: 8776576)
Neurosci Lett. 2005 Jun 24;381(3):252-7. (PMID: 15896479)
J Biol Chem. 2002 Aug 30;277(35):32353-9. (PMID: 12058024)
Glia. 1991;4(2):225-32. (PMID: 1827780)
J Neurosci Res. 2009 Feb;87(2):333-41. (PMID: 18924174)
Exp Transl Stroke Med. 2009 Oct 24;1:6. (PMID: 20150984)
J Neurosci Methods. 2005 Nov 30;149(1):50-6. (PMID: 15975663)
Nature. 1997 Apr 17;386(6626):724-8. (PMID: 9109490)
J Biol Chem. 2005 Aug 19;280(33):29533-42. (PMID: 15967790)
معلومات مُعتمدة: R01 NS052839 United States NS NINDS NIH HHS; R01 NS052839-04 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (Intracellular Signaling Peptides and Proteins)
0 (Myelin Proteins)
0 (O Antigens)
126968-45-4 (Versicans)
EC 1.1.1.27 (L-Lactate Dehydrogenase)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20101002 Date Completed: 20110321 Latest Revision: 20211020
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC2993822
DOI: 10.1016/j.brainres.2010.09.078
PMID: 20883670
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6240
DOI:10.1016/j.brainres.2010.09.078