التفاصيل البيبلوغرافية
| العنوان: |
Pharmacologically active metabolites of currently marketed drugs: potential resources for new drug discovery and development. |
| المؤلفون: |
Kang MJ; Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul, South Korea., Song WH, Shim BH, Oh SY, Lee HY, Chung EY, Sohn Y, Lee J |
| المصدر: |
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2010 Oct; Vol. 130 (10), pp. 1325-37. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Nihon Yakugakkai Country of Publication: Japan NLM ID: 0413613 Publication Model: Print Cited Medium: Print ISSN: 0031-6903 (Print) Linking ISSN: 00316903 NLM ISO Abbreviation: Yakugaku Zasshi Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Tokyo : Nihon Yakugakkai |
| مواضيع طبية MeSH: |
Drug Discovery* , Pharmacokinetics* |
| مستخلص: |
Biotransformation is the major clearance mechanism of therapeutic agents from the body. Biotransformation is known not only to facilitate the elimination of drugs by changing the molecular structure to more hydrophilic, but also lead to pharmacological inactivation of therapeutic compounds. However, in some cases, the biotransformation of drugs can lead to the generation of pharmacologically active metabolites, responsible for the pharmacological actions. This review provides an update of the kinds of pharmacologically active metabolites and some of their individual pharmacological and pharmacokinetic aspects, and describes their importance as resources for drug discovery and development. |
| تواريخ الأحداث: |
Date Created: 20101009 Date Completed: 20101230 Latest Revision: 20190724 |
| رمز التحديث: |
20221213 |
| DOI: |
10.1248/yakushi.130.1325 |
| PMID: |
20930485 |
| قاعدة البيانات: |
MEDLINE |
