دورية أكاديمية
[Expression of nuclear hormone receptors PPAR, LXR and RXR in the liver and lipid and glucose levels in blood in susceptible and resistant to hepatocarcinogenesis mice strains].
| العنوان: | [Expression of nuclear hormone receptors PPAR, LXR and RXR in the liver and lipid and glucose levels in blood in susceptible and resistant to hepatocarcinogenesis mice strains]. |
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| المؤلفون: | Pivovarova EN, Baginskaia NV, Perepechaeva ML, Il'nitskaia SI, Dushkin MI |
| المصدر: | Biomeditsinskaia khimiia [Biomed Khim] 2010 Jul-Aug; Vol. 56 (4), pp. 480-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk Country of Publication: Russia (Federation) NLM ID: 101196966 Publication Model: Print Cited Medium: Print ISSN: 2310-6972 (Print) Linking ISSN: 23106905 NLM ISO Abbreviation: Biomed Khim Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk, 2003- |
| مواضيع طبية MeSH: | Blood Glucose/*metabolism , Lipids/*blood , Liver Neoplasms/*metabolism , Orphan Nuclear Receptors/*biosynthesis , Peroxisome Proliferator-Activated Receptors/*biosynthesis , Retinoid X Receptors/*biosynthesis, Animals ; Corticosterone/blood ; Disease Susceptibility ; Insulin/blood ; Liver Neoplasms/etiology ; Liver X Receptors ; Male ; Mice ; Mice, Inbred Strains ; Species Specificity |
| مستخلص: | Earlier it was shown that male mice of the DD/He strain were highly susceptible to ortho-aminoasotoluene (OAT) induced hepatocarcinogenesis, and resistant to spontaneous liver tumor development as compared to the CC57BR/Mv strain. In the present work we have made a comparative investigation of peroxisome proliferator-activated receptor (PPAR), liver X-receptor (LXR) and retinoic X-receptor (RXR) mRNA levels in liver as well as concentrations of corticosterone, glucose, lipids and insulin in blood of male DD/He and CC57BR/Mv mice. Using the multiplex RT-PCR method it was found that PPAR-alpha, PPAR-gamma, RXR-alpha and RXR-beta mRNA content was essentially decreased in the liver of DD mice as compared to mice of the CC57BR strain. No significant interstrain differences of LXR-alpha and LXR-beta mRNA content were found. In DD micetere was more then the 3-fold decrease of blood content of corticosterone, which is involved in PPAR and RXR regulation. DD mice demonstrated a significant decrease in blood serum glucose and insulin concentrations as well as higher reactivity to insulin as compared with CC57BR mice. Elevated blood total cholesterol and cholesterol HDL level were found in DD mice whereas triglyceride content was basically the same in both mouse strains. It is known that glucocorticoids, PPAR and RXR play crucial role in transcription regulation of inflammation response. Therefore our data allow to suggest that decreased corticosterone level in blood, PPAR and RXR mRNA content in liver of the DD strain may lead to induction of inflammation by OAT exposure, resulting in a high incidence of tumorigenesis in this strain. |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Insulin) 0 (Lipids) 0 (Liver X Receptors) 0 (Nr1h3 protein, mouse) 0 (Orphan Nuclear Receptors) 0 (Peroxisome Proliferator-Activated Receptors) 0 (Retinoid X Receptors) W980KJ009P (Corticosterone) |
| تواريخ الأحداث: | Date Created: 20101102 Date Completed: 20101109 Latest Revision: 20191111 |
| رمز التحديث: | 20231215 |
| DOI: | 10.18097/pbmc20105604480 |
| PMID: | 21032898 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2310-6972 |
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| DOI: | 10.18097/pbmc20105604480 |