دورية أكاديمية
أعرض في EDS

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.

التفاصيل البيبلوغرافية
العنوان: A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.
المؤلفون: Neely GG; Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 3-5, A-1030 Vienna, Austria., Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM
المصدر: Cell [Cell] 2010 Nov 12; Vol. 143 (4), pp. 628-38.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
مواضيع طبية MeSH: Calcium Channels/*genetics , Drosophila/*genetics , Drosophila Proteins/*genetics , Pain/*genetics, Adult ; Animals ; Back Pain/genetics ; Calcium Channels/metabolism ; Drosophila Proteins/metabolism ; Gene Knockdown Techniques ; Genome-Wide Association Study ; Hot Temperature ; Humans ; Mice ; Polymorphism, Single Nucleotide ; RNA Interference
مستخلص: Worldwide, acute, and chronic pain affects 20% of the adult population and represents an enormous financial and emotional burden. Using genome-wide neuronal-specific RNAi knockdown in Drosophila, we report a global screen for an innate behavior and identify hundreds of genes implicated in heat nociception, including the α2δ family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (α2δ3) also exhibit impaired behavioral heat pain sensitivity. In addition, in humans, α2δ3 SNP variants associate with reduced sensitivity to acute noxious heat and chronic back pain. Functional imaging in α2δ3 mutant mice revealed impaired transmission of thermal pain-evoked signals from the thalamus to higher-order pain centers. Intriguingly, in α2δ3 mutant mice, thermal pain and tactile stimulation triggered strong cross-activation, or synesthesia, of brain regions involved in vision, olfaction, and hearing.
(Copyright © 2010 Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Cell. 2010 Nov 12;143(4):505-7. (PMID: 21074043)
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معلومات مُعتمدة: R01 NS039518-09 United States NS NINDS NIH HHS; R01 NS039518 United States NS NINDS NIH HHS; R37 NS039518 United States NS NINDS NIH HHS; P01 NS044232 United States NS NINDS NIH HHS; F32 GM086207-02 United States GM NIGMS NIH HHS; R01 NS038253 United States NS NINDS NIH HHS; F32 GM086207 United States GM NIGMS NIH HHS; P01 NS072040 United States NS NINDS NIH HHS; R01 NS058870-04 United States NS NINDS NIH HHS; R01 NS058870 United States NS NINDS NIH HHS; R01 NS038253-12 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (CACNA2D3 protein, human)
0 (CACNA2D3 protein, mouse)
0 (Calcium Channels)
0 (Drosophila Proteins)
0 (stj protein, Drosophila)
تواريخ الأحداث: Date Created: 20101116 Date Completed: 20101208 Latest Revision: 20220317
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3040441
DOI: 10.1016/j.cell.2010.09.047
PMID: 21074052
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4172
DOI:10.1016/j.cell.2010.09.047