دورية أكاديمية
Intraarticular pressure and the relationship between synovial perfusion and metabolic demand.
| العنوان: | Intraarticular pressure and the relationship between synovial perfusion and metabolic demand. |
|---|---|
| المؤلفون: | James MJ; Morialta Trust Rheumatology Research Laboratory, Royal Adelaide Hospital, Australia., Cleland LG, Rofe AM, Leslie AL |
| المصدر: | The Journal of rheumatology [J Rheumatol] 1990 Apr; Vol. 17 (4), pp. 521-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print Cited Medium: Print ISSN: 0315-162X (Print) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Toronto : Journal Of Rheumatology Publishing Co Original Publication: Toronto. |
| مواضيع طبية MeSH: | Joints/*physiology , Synovial Fluid/*metabolism, Adult ; Aged ; Carbon Dioxide/metabolism ; Energy Metabolism ; Glucose/metabolism ; Humans ; Hydrogen-Ion Concentration ; Lactates/metabolism ; Lactic Acid ; Middle Aged ; Osmolar Concentration ; Perfusion ; Pressure ; Uric Acid/metabolism |
| مستخلص: | We examined the influence of intraarticular pressure on products of synovial energy metabolism in patients with knee effusions. A range of intraarticular pressures was generated by controlled flexion. Pressures greater than or equal to 45 mm Hg were associated with increased synovial fluid lactate concentrations and pCO2, and decreased pH. Our results suggest that pressures greater than or equal to 45 mm Hg, which we also observed during standing and walking, can cause synovial ischemia and hypoxia manifest in a perfusion/metabolic demand mismatch. Monitoring changes in SF concentrations of uric acid did not provide consistent evidence for accelerated purine degradation following periods of inadequate perfusion. Overall, our results suggest that synovial blood flow can be compromised by modest elevations in intraarticular pressure in the range encountered during daily activity in patients with knee effusions. |
| المشرفين على المادة: | 0 (Lactates) 142M471B3J (Carbon Dioxide) 268B43MJ25 (Uric Acid) 33X04XA5AT (Lactic Acid) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 19900401 Date Completed: 19900711 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 2112198 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0315-162X |
|---|