دورية أكاديمية
أعرض في EDS

Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation.

التفاصيل البيبلوغرافية
العنوان: Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation.
المؤلفون: Deyter GM; Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Furuta T, Kurasawa Y, Schumacher JM
المصدر: PLoS genetics [PLoS Genet] 2010 Nov 24; Vol. 6 (11), pp. e1001218. Date of Electronic Publication: 2010 Nov 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: Electronic Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Anaphase* , Chromosome Segregation*, Caenorhabditis elegans/*cytology , Caenorhabditis elegans/*metabolism , Caenorhabditis elegans Proteins/*metabolism , Cyclin B/*metabolism , Spindle Apparatus/*metabolism, Animals ; Caenorhabditis elegans/embryology ; Cell Nucleus/metabolism ; Cytoplasmic Dyneins/metabolism ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Gene Deletion ; Kinetochores/metabolism ; Metaphase ; RNA Interference ; Time Factors
مستخلص: The master regulators of the cell cycle are cyclin-dependent kinases (Cdks), which influence the function of a myriad of proteins via phosphorylation. Mitotic Cdk1 is activated by A-type, as well as B1- and B2-type, cyclins. However, the role of a third, conserved cyclin B family member, cyclin B3, is less well defined. Here, we show that Caenorhabditis elegans CYB-3 has essential and distinct functions from cyclin B1 and B2 in the early embryo. CYB-3 is required for the timely execution of a number of cell cycle events including completion of the MII meiotic division of the oocyte nucleus, pronuclear migration, centrosome maturation, mitotic chromosome condensation and congression, and, most strikingly, progression through the metaphase-to-anaphase transition. Our experiments reveal that the extended metaphase delay in CYB-3-depleted embryos is dependent on an intact spindle assembly checkpoint (SAC) and results in salient defects in the architecture of holocentric metaphase chromosomes. Furthermore, genetically increasing or decreasing dynein activity results in the respective suppression or enhancement of CYB-3-dependent defects in cell cycle progression. Altogether, these data reveal that CYB-3 plays a unique, essential role in the cell cycle including promoting mitotic dynein functionality and alleviation of a SAC-dependent block in anaphase chromosome segregation.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: P30 CA016672 United States CA NCI NIH HHS; CA16672 United States CA NCI NIH HHS; T32 HD007325 United States HD NICHD NIH HHS; T32 CA009299 29 United States CA NCI NIH HHS; R01 GM062181 United States GM NIGMS NIH HHS; T32 HD007325 21 United States HD NICHD NIH HHS; T32 CA009299 United States CA NCI NIH HHS; R01 GM62181 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (CYB-3 protein, C elegans)
0 (Caenorhabditis elegans Proteins)
0 (Cyclin B)
EC 3.6.4.2 (Cytoplasmic Dyneins)
EC 3.6.4.2 (DHC-1 protein, C elegans)
تواريخ الأحداث: Date Created: 20101203 Date Completed: 20110228 Latest Revision: 20211020
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC2991249
DOI: 10.1371/journal.pgen.1001218
PMID: 21124864
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7404
DOI:10.1371/journal.pgen.1001218