دورية أكاديمية
أعرض في EDS

Purpose-driven biomaterials research in liver-tissue engineering.

التفاصيل البيبلوغرافية
العنوان: Purpose-driven biomaterials research in liver-tissue engineering.
المؤلفون: Ananthanarayanan A; National University of Singapore, MD9 #03-03, 2 Medical Drive, Singapore., Narmada BC, Mo X, McMillian M, Yu H
المصدر: Trends in biotechnology [Trends Biotechnol] 2011 Mar; Vol. 29 (3), pp. 110-8. Date of Electronic Publication: 2010 Dec 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE
أسماء مطبوعة: Publication: Barking : Elsevier Science Publishers
Original Publication: [Amsterdam, Netherlands : Elsevier Science Publishers B.V. (Biomedical Division), c1983-
مواضيع طبية MeSH: Tissue Engineering*, Liver/*cytology, Animals ; Biocompatible Materials ; Embryonic Stem Cells/cytology ; Hepatocytes/physiology ; Humans ; Liver/physiology ; Liver Regeneration ; Tissue Scaffolds
مستخلص: Bottom-up engineering of microscale tissue ("microtissue") constructs to recapitulate partially the complex structure-function relationships of liver parenchyma has been realized through the development of sophisticated biomaterial scaffolds, liver-cell sources, and in vitro culture techniques. With regard to in vivo applications, the long-lived stem/progenitor cell constructs can improve cell engraftment, whereas the short-lived, but highly functional hepatocyte constructs stimulate host liver regeneration. With regard to in vitro applications, microtissue constructs are being adapted or custom-engineered into cell-based assays for testing acute, chronic and idiosyncratic toxicities of drugs or pathogens. Systems-level methods and computational models that represent quantitative relationships between biomaterial scaffolds, cells and microtissue constructs will further enable their rational design for optimal integration into specific biomedical applications.
(Copyright © 2010 Elsevier Ltd. All rights reserved.)
المشرفين على المادة: 0 (Biocompatible Materials)
تواريخ الأحداث: Date Created: 20101207 Date Completed: 20110414 Latest Revision: 20110221
رمز التحديث: 20231215
DOI: 10.1016/j.tibtech.2010.10.006
PMID: 21129798
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3096
DOI:10.1016/j.tibtech.2010.10.006