دورية أكاديمية
Purpose-driven biomaterials research in liver-tissue engineering.
العنوان: | Purpose-driven biomaterials research in liver-tissue engineering. |
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المؤلفون: | Ananthanarayanan A; National University of Singapore, MD9 #03-03, 2 Medical Drive, Singapore., Narmada BC, Mo X, McMillian M, Yu H |
المصدر: | Trends in biotechnology [Trends Biotechnol] 2011 Mar; Vol. 29 (3), pp. 110-8. Date of Electronic Publication: 2010 Dec 02. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 8310903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3096 (Electronic) Linking ISSN: 01677799 NLM ISO Abbreviation: Trends Biotechnol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Barking : Elsevier Science Publishers Original Publication: [Amsterdam, Netherlands : Elsevier Science Publishers B.V. (Biomedical Division), c1983- |
مواضيع طبية MeSH: | Tissue Engineering*, Liver/*cytology, Animals ; Biocompatible Materials ; Embryonic Stem Cells/cytology ; Hepatocytes/physiology ; Humans ; Liver/physiology ; Liver Regeneration ; Tissue Scaffolds |
مستخلص: | Bottom-up engineering of microscale tissue ("microtissue") constructs to recapitulate partially the complex structure-function relationships of liver parenchyma has been realized through the development of sophisticated biomaterial scaffolds, liver-cell sources, and in vitro culture techniques. With regard to in vivo applications, the long-lived stem/progenitor cell constructs can improve cell engraftment, whereas the short-lived, but highly functional hepatocyte constructs stimulate host liver regeneration. With regard to in vitro applications, microtissue constructs are being adapted or custom-engineered into cell-based assays for testing acute, chronic and idiosyncratic toxicities of drugs or pathogens. Systems-level methods and computational models that represent quantitative relationships between biomaterial scaffolds, cells and microtissue constructs will further enable their rational design for optimal integration into specific biomedical applications. (Copyright © 2010 Elsevier Ltd. All rights reserved.) |
المشرفين على المادة: | 0 (Biocompatible Materials) |
تواريخ الأحداث: | Date Created: 20101207 Date Completed: 20110414 Latest Revision: 20110221 |
رمز التحديث: | 20231215 |
DOI: | 10.1016/j.tibtech.2010.10.006 |
PMID: | 21129798 |
قاعدة البيانات: | MEDLINE |
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