دورية أكاديمية
Histologic study of urethral extracellular matrix and collagen from aging and long-term alloxan-induced diabetic male rats.
| العنوان: | Histologic study of urethral extracellular matrix and collagen from aging and long-term alloxan-induced diabetic male rats. |
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| المؤلفون: | Rodrigues AA Jr; Department of Anatomy and Surgery, University of São Paulo Faculty of Medicine of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil. aantunesrj@yahoo.com.br, Suaid HJ, Fazan VP, Reis RB, Cologna AJ, Tucci S Jr, Cassini MF, Foss MC, Martins AC |
| المصدر: | Urology [Urology] 2011 Feb; Vol. 77 (2), pp. 510.e6-11. Date of Electronic Publication: 2010 Dec 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0366151 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-9995 (Electronic) Linking ISSN: 00904295 NLM ISO Abbreviation: Urology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Science Original Publication: Ridgewood, N.J., Professional Medical Services Co. |
| مواضيع طبية MeSH: | Aging/*pathology , Collagen/*analysis , Diabetes Mellitus, Experimental/*pathology , Extracellular Matrix/*pathology , Urethra/*chemistry , Urethra/*pathology, Alloxan/administration & dosage ; Animals ; Diabetes Mellitus, Experimental/chemically induced ; Male ; Rats ; Rats, Wistar ; Time Factors |
| مستخلص: | Objectives: To evaluate the histological alterations of extracellular matrix in long-term alloxan-induced diabetes and aging urethras of male rats with descriptions of total connective tissue, muscle layer and collagen types I and III relative amounts. Methods: Histologic evaluations were performed in 3 animal groups: group 1, 8 weeks old; group 2, 44 weeks old; and group 3, 44 weeks old with alloxan-induced diabetes. The muscle layer thickness, extracellular matrix fibrosis, and collagen were quantified on digital images of the urethral samples. Results: A higher total thickness and muscle layer thickness and higher connective tissue and collagen content were observed in the urethras of group 3. No changes in the collagen type III/I ratio were found in the urethra of groups 2 and 3. Conclusions: Our results suggest that the morphologic alterations of the urethra should also be considered in long-term studies of diabetic lower urinary tract dysfunction. These morphologic alterations due to diabetes differ from the changes induced by aging itself and could represent a final stage in decompensate urethras. Further studies are necessary to establish the real influence of the urethral morphologic changes on lower urinary tract diabetes dysfunction. (Copyright © 2011 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 6SW5YHA5NG (Alloxan) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20101215 Date Completed: 20110323 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.urology.2010.09.033 |
| PMID: | 21146862 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1527-9995 |
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| DOI: | 10.1016/j.urology.2010.09.033 |